Using Hollow Carbon Nanospheres as a Light-Induced Free Radical Generator To Overcome Chemotherapy Resistance
Wang LM(王黎明); Wang, LM; Sun, Q; Wang, X; Wen, T; Yin, JJ; Wang, PY; Bai, R; Zhang, XQ; Zhang, LH; Lu, AH; Chen, CY
刊名JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2015
卷号137期号:5页码:1947-1955
学科分类Chemistry
DOI10.1021/ja511560b
文章类型Article
英文摘要Under evolutionary pressure from chemotherapy, cancer cells develop resistance characteristics such as a low redox state, which eventually leads to treatment failures. An attractive option for combatting resistance is producing a high concentration of produced free radicals in situ. Here, we report the production and use of dispersible hollow carbon nanospheres (HCSs) as a novel platform for delivering the drug doxorubicine (DOX) and generating additional cellular reactive oxygen species using near-infrared laser irradiation. These irradiated HCSs catalyzed sufficiently persistent free radicals to produce a large number of heat shock factor-1 protein homotrimers, thereby suppressing the activation and function of resistance-related genes. Laser irradiation also promoted the release of DOX from lysosomal DOX@HCSs into the cytoplasm so that it could enter cell nuclei. As a result, DOX@HCSs reduced the resistance of human breast cancer cells (MCF-7/ADR) to DOX through the synergy among photothermal effects, increased generation of free radicals, and chemotherapy with the aid of laser irradiation. HCSs can provide a unique and versatile platform for combatting chemotherapy-resistant cancer cells. These findings provide new clinical strategies and insights for the treatment of resistant cancers.
类目[WOS]Chemistry, Multidisciplinary
收录类别SCI ; EI ; CA
WOS记录号WOS:000349575800037
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被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228092
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Wang LM,Wang, LM,Sun, Q,et al. Using Hollow Carbon Nanospheres as a Light-Induced Free Radical Generator To Overcome Chemotherapy Resistance[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2015,137(5):1947-1955.
APA 王黎明.,Wang, LM.,Sun, Q.,Wang, X.,Wen, T.,...&Chen, CY.(2015).Using Hollow Carbon Nanospheres as a Light-Induced Free Radical Generator To Overcome Chemotherapy Resistance.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,137(5),1947-1955.
MLA 王黎明,et al."Using Hollow Carbon Nanospheres as a Light-Induced Free Radical Generator To Overcome Chemotherapy Resistance".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137.5(2015):1947-1955.
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