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The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure
Chen CY(陈春英); Yu HW(喻宏伟); Zhao JJ(赵九江); Li B(李柏); Zhang PQ(章佩群); Chai ZF(柴之芳); Chen, CY; Yu, HW; Zhao, JJ; Li, B; Qu, LY; Liu, SP; Zhang, PQ; Chai, ZF
2006
发表期刊ENVIRONMENTAL HEALTH PERSPECTIVES
卷号114期号:2页码:#REF!
通讯作者Chen, CY (reprint author), Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Analyt Tech, POB 918, Beijing 100049, Peoples R China.
文章类型Article; Proceedings Paper
摘要Many studies have found that mercury (Hg) exposure is associated with selenium (Se) accumulation in vivo. However, human studies are limited. To study the interaction between Se and Hg, we investigated the total Se and Hg concentrations in body fluids and serum Se-containing proteins in individuals exposed to high concentrations of Hg. Our objective was to elucidate the possible roles of serum Se and selenoproteins in transporting and binding Hg in human populations. We collected data from 72 subjects: 35 had very low Hg exposure as evidenced by mean Hg concentrations of 0.91 and 1.25 ng/mL measured in serum and urine, respectively; 37 had high exposure (mean Hg concentrations of 38.5 and 86.8 ng/mL measured in serum and urine, respectively). An association between Se and Hg was found in urine (r = 0.625; p < 0.001) but not in serum. Hg exposure may affect Se concentrations and selenoprotein distribution in human serum. Expression of both selenoprotein P and glutathione peroxidase (GSH-Px) was greatly increased in Hg miners. These increases were accompanied by elevated Se concentrations in serum. In addition, selenoprotein P bound more Hg at higher Hg exposure concentrations. Biochemical observations revealed that both GSH-Px activity and malondialdehyde concentrations increased in serum of the Hg-exposed group. This study aids in the understanding of the interaction between Se and Hg. Selenoproteins play two important roles in protecting against Hg toxicity. First, they may bind more Hg through their highly reactive selenol group, and second, their antioxidative properties help eliminate the reactive oxygen species induced by Hg in vivo.
关键词antagonism Hg-exposed subjects mercury selenium selenoproteins serum
学科领域Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology
DOI10.1289/ehp.7861
收录类别SCI
WOS类目Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS记录号WOS:000235226300054
引用统计
被引频次:108[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/227488
专题院士
实验物理中心
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GB/T 7714
Chen CY,Yu HW,Zhao JJ,et al. The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2006,114(2):#REF!.
APA 陈春英.,喻宏伟.,赵九江.,李柏.,章佩群.,...&Chai, ZF.(2006).The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure.ENVIRONMENTAL HEALTH PERSPECTIVES,114(2),#REF!.
MLA 陈春英,et al."The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure".ENVIRONMENTAL HEALTH PERSPECTIVES 114.2(2006):#REF!.
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