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Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice
Wang B(汪冰); Feng WY(丰伟悦); Wang M(王萌); Zhu MT(朱墨桃); Ou YH(欧阳宏); Shi JW(史俊稳); Zhao YL(赵宇亮); Chai ZF(柴之芳); Wang, B; Feng, WY; Wang, M; Wang, TC; Gu, YQ; Zhu, MT; Ouyang, H; Shi, JW; Zhang, F; Zhao, YL; Chai, ZF; Wang, HF; Wang, J
2008
发表期刊JOURNAL OF NANOPARTICLE RESEARCH
卷号10期号:2页码:#REF!
通讯作者Feng, WY (reprint author), Chinese Acad Sci, Lab Bioenvironm Hlth Sci Nanoscale Mat & Nanosafe, Beijing 100049, Peoples R China.
摘要In this work, the acute oral toxicity of 20- and 120-nm ZnO powder at doses of 1-, 2-, 3-, 4-, 5-g/kg body weight was evaluated referred to the OECD guidelines for testing of chemicals. As the results, both 20- and 120-nm ZnO belong to non-toxic chemicals according to the Globally Harmonized Classification System (GHS) for the classification of chemicals. The distribution determination showed that Zn was mainly retained in the bone, kidney and pancreas after 20- and 120-nm ZnO administration. However, the results of blood measurement suggest that the increase in blood viscosity could be induced by low and median dose of 20-nm ZnO but high dose of 120-nm ZnO. The pathological examination showed that the 120-nm ZnO treated mice had dose-effect pathological damages in stomach, liver, heart and spleen, whereas, 20-nm ZnO displayed negative dose-effect damages in liver, spleen and pancreas. Therefore, we conclude that the liver, spleen, heart, pancreas and bone are the target organs for 20- and 120-nm ZnO oral exposure. More attention should be paid on the potential toxicity induced by low dose of 20-nm ZnO oral exposure.
文章类型Article
关键词acute oral toxicity nano-meter zinc oxide powder submicro-meter zinc oxide powder mice toxicology health effects medicine
学科领域Chemistry; Science & Technology - Other Topics; Materials Science
DOI10.1007/s11051-007-9245-3
收录类别SCI
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000251730400003
引用统计
被引频次:175[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/227271
专题院士
多学科研究中心
推荐引用方式
GB/T 7714
Wang B,Feng WY,Wang M,et al. Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice[J]. JOURNAL OF NANOPARTICLE RESEARCH,2008,10(2):#REF!.
APA 汪冰.,丰伟悦.,王萌.,朱墨桃.,欧阳宏.,...&Wang, J.(2008).Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice.JOURNAL OF NANOPARTICLE RESEARCH,10(2),#REF!.
MLA 汪冰,et al."Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice".JOURNAL OF NANOPARTICLE RESEARCH 10.2(2008):#REF!.
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