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Element distribution in the brain sections of rats measured by synchrotron radiation X-ray fluorescence
Liu NQ(刘年庆); Zhang F(张芳); Zhang ZY(张智勇); Chai ZF(柴之芳); Huang YY(黄宇营); He W(何伟); Liu, NQ; Zhang, E; Wang, XE; Zhang, ZY; Chai, ZF; Huang, YY; He, W; Zhao, XQ; Zuo, AJ; Yang, R
2004
Source PublicationSPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
Volume59Issue:2Pages:#REF!
Corresponding AuthorLiu, NQ (reprint author), Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Analyt Tech, POB 918, Beijing 100039, Peoples R China.
SubtypeArticle
AbstractThe concentration of trace elements in brain sections was measured by synchrotron radiation X-ray fluorescence. The relative concentration was calculated by means of the normalization of Compton scattering intensity approximately 22 keV, after the normalization for collecting time of X-ray spectrum and the counting of the ion chamber, and subtracting the contribution of the polycarbonate film for supporting sample. Furthermore, the statistical evaluation of the element distribution in various regions of the brain sections of the 20-day-old rats was tested. For investigating the distribution of elements in the brain of iodine deficient rats, Wistar rats were fed with iodine deficient diet and deionized water (ID group). The rats were fed the same iodine deficient diet, but drank KIO3 solution as control (CT group). The results showed that the contents of calcium (Ca) in thalamus (TH) and copper (Cu) and iron (Fe) in cerebral cortex (CX) of ID rats were significantly lower than that of control rats, while the contents of phosphor (P), sulfur (S), potassium (K), rubidium (Rb), bromine (Br), chlorine (CI), zinc (Zn), Ca and Cu of ID in hippocampus (H) and the contents of Br, Cl, Zn and Ca in cerebral cortex of ID rats were significantly higher. Especially, the difference of Br, Cl, Zn and Ca in H between ID and CT was more significant. The contents of all elements measured in H were higher than (or equal to) CX and/or TH for both groups, except low Cl of the control rats. Furthermore Zn and Cu contents along the hippocampal fissure in both groups were 1.5 (P<0.001) and 0.87(P<0.03) times higher than in hippocampus, respectively. Considering the results of cluster analysis our study shows that the marked alterations in the spatial distribution of Zn and Ca of ID rats brain during brain development stages. In addition, the effect of the perfusion with 0.9% NaCl solution before taking brain on the distribution of elements in the brain sections was observed and discussed. (C) 2003 Elsevier B.V. All rights reserved.
Keywordtrace element cerebral cortex hippocampus thalamus hippocampal fissure perfusion synchrotron radiation X-ray fluorescence
Subject AreaSpectroscopy
DOI10.1016/j.sab.2003.12.006
Indexed BySCI ; ADS
WOS SubjectSpectroscopy
WOS IDWOS:000220132300011
ADS Bibcode2004AcSpe..59..255L
ADS URLhttps://ui.adsabs.harvard.edu/abs/2004AcSpe..59..255L
ADS CITATIONShttps://ui.adsabs.harvard.edu/abs/2004AcSpe..59..255L/citations
Citation statistics
Cited Times:5 [ADS]
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/227222
Collection院士
Recommended Citation
GB/T 7714
Liu NQ,Zhang F,Zhang ZY,et al. Element distribution in the brain sections of rats measured by synchrotron radiation X-ray fluorescence[J]. SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY,2004,59(2):#REF!.
APA 刘年庆.,张芳.,张智勇.,柴之芳.,黄宇营.,...&Yang, R.(2004).Element distribution in the brain sections of rats measured by synchrotron radiation X-ray fluorescence.SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY,59(2),#REF!.
MLA 刘年庆,et al."Element distribution in the brain sections of rats measured by synchrotron radiation X-ray fluorescence".SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY 59.2(2004):#REF!.
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