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Characterization of Fe, Cu and Zn in organs of PDAPP transgenic mice by XRF spectrometry
Zhang ZY(张智勇); Liu NQ(刘年庆); Li FL(李福亮); Zhang, ZY; Liu, NQ; Li, FL; Zhang, J; Zhu, H; Qin, C; Zou, ZY; Tang, XW
Source PublicationX-RAY SPECTROMETRY
Corresponding AuthorLiu, NQ (reprint author), Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, POB 918, Beijing 100049, Peoples R China.
AbstractA large body of evidence indicates that abnormalities in the levels of iron, copper and zinc and their metabolism are associated with neurodegenerative diseases. However, it is difficult to decide whether any observed changes of trace elements reflect the primary disease process or are secondary to a primary process or mechanism. In the present study, Fe, Cu and Zn in organs of transgenic mice which express the familial Alzheimer's disease (AD) gene and normal mice of the same species and ages were determined by X-ray fluorescence (XRF) spectrometry. The results show that Fe concentrations in a variety of organs and tissues were significantly increased whereas Zn concentrations decreased in the transgenic mice as compared with the 'normals'. The levels of Cu in transgenic mice were also altered. Data obtained in the present study suggest that expression of the familial AD gene in mice results in altered homeostasis of Fe, Cu and Zn in organs of the animals, which may in turn accelerate the process of neurodegeneration. Copyright (C) 2006 John Wiley & Sons, Ltd.
Subject AreaSpectroscopy
Indexed BySCI ; ADS
WOS SubjectSpectroscopy
WOS IDWOS:000239321500009
ADS Bibcode2006XRS....35..253Z
ADS URLhttps://ui.adsabs.harvard.edu/abs/2006XRS....35..253Z
ADS CITATIONShttps://ui.adsabs.harvard.edu/abs/2006XRS....35..253Z/citations
Citation statistics
Cited Times:1 [ADS]
Document Type期刊论文
Recommended Citation
GB/T 7714
Zhang ZY,Liu NQ,Li FL,et al. Characterization of Fe, Cu and Zn in organs of PDAPP transgenic mice by XRF spectrometry[J]. X-RAY SPECTROMETRY,2006,35(4):#REF!.
APA 张智勇.,刘年庆.,李福亮.,Zhang, ZY.,Liu, NQ.,...&Tang, XW.(2006).Characterization of Fe, Cu and Zn in organs of PDAPP transgenic mice by XRF spectrometry.X-RAY SPECTROMETRY,35(4),#REF!.
MLA 张智勇,et al."Characterization of Fe, Cu and Zn in organs of PDAPP transgenic mice by XRF spectrometry".X-RAY SPECTROMETRY 35.4(2006):#REF!.
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