Characterization of Fe, Cu and Zn in organs of PDAPP transgenic mice by XRF spectrometry
Zhang ZY(张智勇); Liu NQ(刘年庆); Li FL(李福亮); Zhang, ZY; Liu, NQ; Li, FL; Zhang, J; Zhu, H; Qin, C; Zou, ZY; Tang, XW
刊名X-RAY SPECTROMETRY
2006
卷号35期号:4页码:#REF!
学科分类Spectroscopy
DOI10.1002/xrs.898
通讯作者Liu, NQ (reprint author), Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, POB 918, Beijing 100049, Peoples R China.
文章类型Article
英文摘要A large body of evidence indicates that abnormalities in the levels of iron, copper and zinc and their metabolism are associated with neurodegenerative diseases. However, it is difficult to decide whether any observed changes of trace elements reflect the primary disease process or are secondary to a primary process or mechanism. In the present study, Fe, Cu and Zn in organs of transgenic mice which express the familial Alzheimer's disease (AD) gene and normal mice of the same species and ages were determined by X-ray fluorescence (XRF) spectrometry. The results show that Fe concentrations in a variety of organs and tissues were significantly increased whereas Zn concentrations decreased in the transgenic mice as compared with the 'normals'. The levels of Cu in transgenic mice were also altered. Data obtained in the present study suggest that expression of the familial AD gene in mice results in altered homeostasis of Fe, Cu and Zn in organs of the animals, which may in turn accelerate the process of neurodegeneration. Copyright (C) 2006 John Wiley & Sons, Ltd.
类目[WOS]Spectroscopy
收录类别SCI
WOS记录号WOS:000239321500009
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/227214
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
推荐引用方式
GB/T 7714
Zhang ZY,Liu NQ,Li FL,et al. Characterization of Fe, Cu and Zn in organs of PDAPP transgenic mice by XRF spectrometry[J]. X-RAY SPECTROMETRY,2006,35(4):#REF!.
APA 张智勇.,刘年庆.,李福亮.,Zhang, ZY.,Liu, NQ.,...&Tang, XW.(2006).Characterization of Fe, Cu and Zn in organs of PDAPP transgenic mice by XRF spectrometry.X-RAY SPECTROMETRY,35(4),#REF!.
MLA 张智勇,et al."Characterization of Fe, Cu and Zn in organs of PDAPP transgenic mice by XRF spectrometry".X-RAY SPECTROMETRY 35.4(2006):#REF!.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2627.pdf(120KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[张智勇]的文章
[刘年庆]的文章
[李福亮]的文章
百度学术
百度学术中相似的文章
[张智勇]的文章
[刘年庆]的文章
[李福亮]的文章
必应学术
必应学术中相似的文章
[张智勇]的文章
[刘年庆]的文章
[李福亮]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 2627.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。