Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice
Zhang Y(张燕); Li B(李柏); Chen CY(陈春英); Zhang, Y; Li, B; Chen, CY; Gao, ZH
刊名BIOMETALS
2009
卷号22期号:2页码:#REF!
关键词Iron overload Metalloproteins Hepatic distribution SEC-HPLC-ICP-MS
学科分类Biochemistry & Molecular Biology
DOI10.1007/s10534-008-9161-8
通讯作者Chen, CY (reprint author), Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100049, Peoples R China.
文章类型Article
英文摘要Subcellular distribution of metal-containing proteins of Fe, Cu, Zn and Cd were determined in the liver samples of iron overload mice by size exclusion high performance liquid chromatography with on-line coupling to UV and inductively coupled plasma mass spectrometry. Collision cell techniques was used to remove polyatomic interferences for some elements, such as Fe. Comparative molecular weight (MW) information of the elemental fraction was obtained within a retention time of 40 min. Fe was present only in high-MW (HMW) protein; Cu, Zn and Cd were found in different MW proteins. It was also observed that these four elements studied showed predominant association with HMW fractions. Moreover, compared with the normal group, we found that the contents of these elements except Cu significantly increased and the distribution of some elements like Cd changed in iron overload mouse liver. It means that excessive iron accumulation in vivo may affect the metabolism of other element such as Zn and Cd.
类目[WOS]Biochemistry & Molecular Biology
收录类别SCI
WOS记录号WOS:000264546600006
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/227197
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_实验物理中心
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GB/T 7714
Zhang Y,Li B,Chen CY,et al. Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice[J]. BIOMETALS,2009,22(2):#REF!.
APA 张燕.,李柏.,陈春英.,Zhang, Y.,Li, B.,...&Gao, ZH.(2009).Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice.BIOMETALS,22(2),#REF!.
MLA 张燕,et al."Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice".BIOMETALS 22.2(2009):#REF!.
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