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Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice
Zhang Y(张燕); Li B(李柏); Chen CY(陈春英); Zhang, Y; Li, B; Chen, CY; Gao, ZH
2009
发表期刊BIOMETALS
卷号22期号:2页码:#REF!
通讯作者Chen, CY (reprint author), Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100049, Peoples R China.
文章类型Article
摘要Subcellular distribution of metal-containing proteins of Fe, Cu, Zn and Cd were determined in the liver samples of iron overload mice by size exclusion high performance liquid chromatography with on-line coupling to UV and inductively coupled plasma mass spectrometry. Collision cell techniques was used to remove polyatomic interferences for some elements, such as Fe. Comparative molecular weight (MW) information of the elemental fraction was obtained within a retention time of 40 min. Fe was present only in high-MW (HMW) protein; Cu, Zn and Cd were found in different MW proteins. It was also observed that these four elements studied showed predominant association with HMW fractions. Moreover, compared with the normal group, we found that the contents of these elements except Cu significantly increased and the distribution of some elements like Cd changed in iron overload mouse liver. It means that excessive iron accumulation in vivo may affect the metabolism of other element such as Zn and Cd.
关键词Iron overload Metalloproteins Hepatic distribution SEC-HPLC-ICP-MS
学科领域Biochemistry & Molecular Biology
DOI10.1007/s10534-008-9161-8
收录类别SCI
WOS类目Biochemistry & Molecular Biology
WOS记录号WOS:000264546600006
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/227197
专题多学科研究中心
实验物理中心
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GB/T 7714
Zhang Y,Li B,Chen CY,et al. Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice[J]. BIOMETALS,2009,22(2):#REF!.
APA 张燕.,李柏.,陈春英.,Zhang, Y.,Li, B.,...&Gao, ZH.(2009).Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice.BIOMETALS,22(2),#REF!.
MLA 张燕,et al."Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice".BIOMETALS 22.2(2009):#REF!.
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