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Transport of intranasally instilled fine Fe2O3 particles into the brain: Micro-distribution, chemical states, and histopathological observation
Wang B(汪冰); Feng WY(丰伟悦); Wang M(王萌); Shi WJ(史文君); Zhang F(张芳); Ou YH(欧阳宏); Zhao YL(赵宇亮); Chai ZF(柴之芳); Huang YY(黄宇营); Xie YN(谢亚宁); Wang HF(王海峰); Wang J(王静); Wang, B; Feng, WY; Wang, M; Shi, JW; Zhang, F; Ouyang, H; Zhao, YL; Chai, ZF; Huang, YY; Xie, YN; Wang, HF; Wang, J
2007
Source PublicationBIOLOGICAL TRACE ELEMENT RESEARCH
Volume118Issue:3Pages:#REF!
Corresponding AuthorFeng, WY (reprint author), Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing, Peoples R China.
SubtypeArticle
AbstractIt has been demonstrated that inhaled fine (d<2.5 mu m) and ultrafine (d<100 nm) particles produce more severe toxicity than coarse particles. Some recent data support the concept that the central nervous system (CNS) may. be a target for the inhaled fine particulates. This work describes initial observation of the transport of intranasally instilled fine ferric oxide (Fe2O3) particles in animal brain. The iron micro-distribution and chemical state in the mice olfactory bulb and brain stem on day 14 after intranasal instillation of fine Fe2O3 particle (280+/-80 nm) suspension at a single dose of 40 mg/kg body weight were analyzed by synchrotron radiation x-ray fluorescence and x-ray absorption near-edge structure (XANES). The micro-distribution map of iron in the olfactory bulb and brain stem shows an obvious increase of Fe contents in the olfactory nerve and the trigeminus of brain stem, suggesting that Fe2O3 particles were possibly transported via uptake by sensory nerve endings of the olfactory nerve and trigeminus. The XANES results indicate that the ratios of Fe (III)/Fe (II) were increased in the olfactory bulb and brain stem. The further histopathological observation showed that the neuron fatty degeneration occurred in the CA3 area of hippocampus. Such results imply an adverse impact of inhalation of fine Fe2O3 particles on CNS.
Keywordfine ferric oxide particle intranasal instillation olfactory transportation brain micro-distribution chemical state pathological observation
Subject AreaBiochemistry & Molecular Biology; Endocrinology & Metabolism
DOI10.1007/s12011-007-0028-6
Indexed BySCI
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000249558400005
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/227104
Collection院士
多学科研究中心
Recommended Citation
GB/T 7714
Wang B,Feng WY,Wang M,et al. Transport of intranasally instilled fine Fe2O3 particles into the brain: Micro-distribution, chemical states, and histopathological observation[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2007,118(3):#REF!.
APA 汪冰.,丰伟悦.,王萌.,史文君.,张芳.,...&Wang, J.(2007).Transport of intranasally instilled fine Fe2O3 particles into the brain: Micro-distribution, chemical states, and histopathological observation.BIOLOGICAL TRACE ELEMENT RESEARCH,118(3),#REF!.
MLA 汪冰,et al."Transport of intranasally instilled fine Fe2O3 particles into the brain: Micro-distribution, chemical states, and histopathological observation".BIOLOGICAL TRACE ELEMENT RESEARCH 118.3(2007):#REF!.
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