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Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis
Chen, ZC; Cai, S; Jiang, Q; Zhang, CM; Tang, XW
2005
发表期刊CHINESE SCIENCE BULLETIN
卷号50期号:3页码:#REF!
通讯作者Zhang, CM (reprint author), Peking Univ, Coll Life Sci, Dept Cell Biol & Genet, Natl Lab Biomembrane & Membrance Biotechnol, Beijing 100871, Peoples R China.
文章类型Article
摘要Microtubule and microfilament cytoskeletons play key roles in the whole process of cytokinesis. Although a number of hypotheses have been proposed to elucidate the mechanism of cytokinesis by microtubule and actin filament cytoskeletons, many reports are conflicting. In our study, combining the cytoskeletons drug treatments with the time-lapse video technology, we retested the key roles of microtubule and actin filament in cytokinesis. The results showed that depolymerization of microtubules by Nocodazole after the initiation of furrowing would not inhibit the furrow ingression, but obviously decrease the stiffness of daughter cells. Depolymerizing actin filaments by Cytochalasin B before metaphase would inhibit the initiation of furrowing but not chromosome segregation, resulting in the formation of binucleate cells; however, depolymerizing actin filaments during anaphase would prevent furrowing and lead to the regress of established furrow, also resulting in the formation of binucleate cells. Further, depolymerizing microtubules and actin filaments simultaneously after metaphase would cause the quick regress of the furrow and the formation of binucleate cells. From these results we propose that a successful cytokinesis requires functions and coordination of both the microtubule and actin filament cytoskeletons. Microtubule cytoskeleton may function in the positioning and initiation of cleavage furrow, and the actin filament cytoskeleton may play key roles in the initiation and ingression of the furrow.
关键词cytokinesis microtubule actin Filament cytochalasin B nocodazole
学科领域Science & Technology - Other Topics
DOI10.1360/982004-625
收录类别SCI
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000228412100007
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/227076
专题粒子天体物理中心
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GB/T 7714
Chen, ZC,Cai, S,Jiang, Q,et al. Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis[J]. CHINESE SCIENCE BULLETIN,2005,50(3):#REF!.
APA Chen, ZC,Cai, S,Jiang, Q,Zhang, CM,&Tang, XW.(2005).Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis.CHINESE SCIENCE BULLETIN,50(3),#REF!.
MLA Chen, ZC,et al."Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis".CHINESE SCIENCE BULLETIN 50.3(2005):#REF!.
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