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Mercury and trace element distribution in organic tissues and regional brain of fetal rat after in utero and weaning exposure to low dose of inorganic mercury
Feng WY(丰伟悦); Wang M(王萌); Li B(李柏); Liu J(刘景); Chai ZF(柴之芳); Zhao JJ(赵九江); Deng GL(邓桂龙); Feng, WY; Wang, M; Li, B; Liu, J; Chai, ZF; Zhao, JJ; Deng, GL
2004
Source PublicationTOXICOLOGY LETTERS
Volume152Issue:3Pages:#REF!
Corresponding AuthorFeng, WY (reprint author), Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Analyt Tech, Yu Quan Rd,19B,Shi Jing Shan, Beijing 100039, Peoples R China.
SubtypeArticle
AbstractSince it is still absent data about the toxic risk of low dose, especially an environmentally relevant dose of mercury to fetus after their prenatal exposure, this present work was designed to investigate the metabolism of Hg and its effect on the levels of essential trace elements in the organic tissues and the brain regions of infant rats after their exposure to environmentally relevant low dose of Hg(II) during the whole pregnant and weaning period. The pregnant female rats were exposed to a very low dose of 0.2 mug Hg2+/ml (as HgCl2, 12 rats/group) in drinking water from prenatal day 0 continued to postnatal day 20. The contents of Hg and other elements (Cu, K, Mg, Mn, Na, Ca, Co, Fe, Se and Zn) in the liver, kidney, heart, spleen, pancreas and the brain regions (cerebrum, cerebellum, brain stem, hippocampus, thalamus and the remains) of the maternal and their infant rats were determined. The highest Hg contents were found in kidney of both maternal and infant rats. Considering the percentage of Hg accumulation, approximately 52.7%, 38.7%, and 1.66% were found in kidney, liver and brain for maternal rats, respectively, while 23.7%, 48.9% and 15.6% for infant rats. The important findings in this work were that the low dose of inorganic mercury appeared to accumulate in the brain of offspring and more Hg was present in infant brain than in their mother. As in the brain regions, the highest Hg content was present in infant hippocampus and cerebellum, whereas the Hg contents in maternal brains varied not so much. The imbalances of Fe/Cu, Cu/Zn, Zn/Se mass ratios and the molar ratios of Hg over other elements in the Hg-exposed rats were observed. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Keywordmercury low dose essential trace elements infant rat in utero exposure
Subject AreaToxicology
DOI10.1016/j.toxlet.2004.05.001
Indexed BySCI
WOS SubjectToxicology
WOS IDWOS:000224016600004
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/227037
Collection院士
实验物理中心
多学科研究中心
Recommended Citation
GB/T 7714
Feng WY,Wang M,Li B,et al. Mercury and trace element distribution in organic tissues and regional brain of fetal rat after in utero and weaning exposure to low dose of inorganic mercury[J]. TOXICOLOGY LETTERS,2004,152(3):#REF!.
APA 丰伟悦.,王萌.,李柏.,刘景.,柴之芳.,...&Deng, GL.(2004).Mercury and trace element distribution in organic tissues and regional brain of fetal rat after in utero and weaning exposure to low dose of inorganic mercury.TOXICOLOGY LETTERS,152(3),#REF!.
MLA 丰伟悦,et al."Mercury and trace element distribution in organic tissues and regional brain of fetal rat after in utero and weaning exposure to low dose of inorganic mercury".TOXICOLOGY LETTERS 152.3(2004):#REF!.
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