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Effect of iodine supplement on iodine status and 5 '-deiodinase activity in the brain of neonatal rats with iodine deficiency
Liu NQ(刘年庆); Zhang ZY(张智勇); Chai ZF(柴之芳); Liu, NQ; Zu, AJ; Liang, DC; Zhang, ZY; Guo, G; Chai, ZF
2006
Source PublicationBIOLOGICAL TRACE ELEMENT RESEARCH
Volume114Issue:1-3Pages:#REF!
Corresponding AuthorLiu, NQ (reprint author), Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Analyt Tech, Beijing 100049, Peoples R China.
SubtypeArticle
AbstractThe weanling Wistar rats of iodine deficiency were divided into three groups for supplementation of different levels of iodine (iodine-excessive [IE], iodine-adequate [IA], and iodine-deficient [ID]), with a control group (C). The iodine content in the thyroid was determined by epithermal neutron activation analysis. The activities of 5'-deiodinase and 5-deiodinase in the brains were assayed by determining the conversion ratios of T4 to T3 and rT3, respectively. The thyroid hormones levels in serum were also tested. The results indicated that the ID group had a goiter containing a small amount of iodine, but the IE group had a slightly swollen thyroid with rich iodine; the concentration of iodine per unit mass of thyroid was lower in group IE than in groups IA and C. The highest 5'-deiodinase and lowest 5-deiodinase activities in group ID and the lowest 5'-deiodinase activity in group IE were found. The iodine deficiency or excess resulted in a compensated hypothyroid state. The results suggest that the iodine status and the deiodinases activities would become normal for the rats of iodine deficiency if adequate iodine is supplemented soon after birth. Meanwhile, it is also critical to avoid excessive intake of iodine to reduce the risk for overcorrecting.
Keywordiodine deficiency iodine excess iodine level in thyroid 5 '-deiodinase thyroid hormones
Subject AreaBiochemistry & Molecular Biology; Endocrinology & Metabolism
DOI10.1385/BTER:114:1:207
Indexed BySCI
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000243400700022
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/226940
Collection院士
Recommended Citation
GB/T 7714
Liu NQ,Zhang ZY,Chai ZF,et al. Effect of iodine supplement on iodine status and 5 '-deiodinase activity in the brain of neonatal rats with iodine deficiency[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2006,114(1-3):#REF!.
APA 刘年庆.,张智勇.,柴之芳.,Liu, NQ.,Zu, AJ.,...&Chai, ZF.(2006).Effect of iodine supplement on iodine status and 5 '-deiodinase activity in the brain of neonatal rats with iodine deficiency.BIOLOGICAL TRACE ELEMENT RESEARCH,114(1-3),#REF!.
MLA 刘年庆,et al."Effect of iodine supplement on iodine status and 5 '-deiodinase activity in the brain of neonatal rats with iodine deficiency".BIOLOGICAL TRACE ELEMENT RESEARCH 114.1-3(2006):#REF!.
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