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Subcellular distribution of selenium and Se-containing proteins in human liver
Chen CY(陈春英); Zhang PQ(章佩群); Hou XL(侯小琳); Chai ZF(柴之芳); Chen, CY; Zhang, PQ; Hou, XL; Chai, ZF
刊名BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
1999
卷号1427期号:2页码:#REF!
学科分类Biochemistry & Molecular Biology; Biophysics
DOI10.1016/S0304-4165(99)00013-6
通讯作者Chen, CY (reprint author), Chinese Acad Sci, Inst High Energy Phys, POB 2732, Beijing 100080, Peoples R China.
文章类型Article
英文摘要Selenium is an essential trace element in many living organisms. In the present paper, the subcellular distribution of selenium and Se-containing proteins in human liver samples, which were obtained from normal subjects who had an accidental death, was investigated by differential centrifugation and column chromatography. Selenium was mainly enriched in nuclei, mitochondria and cytosol. Almost half of Se existed in the nuclei due to their large amount in liver and high Se concentration 15-30% of Se was found in small compounds with M-r < 2000 in the liver components separated by dialysis. The average abundance of Se in small molecular mass species of whole-liver was 23.6%, which suggested most of Se associated with biological macromolecules. Eight kinds of Se-containing proteins with molecular mass of 335 +/- 20, 249 +/- 15, 105 +/- 11, 84.6 +/- 5.8, 70.5 +/- 5.4, 45.6 +/- 1.5, 14.8 +/- 2.6, 8.5 +/- 1.2 kDa were found in the subcellular fractions of human liver. Among them the 335, 84.6 and 8.5 kDa proteins were individually present in one subcellular fraction, whereas the others coexisted in two, three or four subcellular fractions. The most abundant Se-containing proteins, 70.5 and 14.8 kDa, accounted for 33.6% and 48.5% in the whole-liver soluble Se-containing protein, respectively. The former was enriched in cytosol and the latter was mainly present in nuclei and mitochondria. (C) 1999 Elsevier Science B.V. All rights reserved.
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
收录类别SCI
WOS记录号WOS:000080029900008
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被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226926
专题院士_期刊论文
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GB/T 7714
Chen CY,Zhang PQ,Hou XL,et al. Subcellular distribution of selenium and Se-containing proteins in human liver[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,1999,1427(2):#REF!.
APA 陈春英.,章佩群.,侯小琳.,柴之芳.,Chen, CY.,...&Chai, ZF.(1999).Subcellular distribution of selenium and Se-containing proteins in human liver.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,1427(2),#REF!.
MLA 陈春英,et al."Subcellular distribution of selenium and Se-containing proteins in human liver".BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1427.2(1999):#REF!.
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