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MXAN analysis of the XANES energy region of LiPDF
Alternative Title用MXAN拟合钩端螺旋体去甲酰化酶XANES谱
Guo XY(郭晓云); Chu WS(储旺盛); Dong YH(董宇辉); Xie YN(谢亚宁); Yang FF(杨飞飞); Wu ZY(吴自玉); Guo, XY; Chu, WS; Gong, WM; Dong, YH; Xie, YN; Yang, FF; Benfatto, M; Wu, ZY
Corresponding AuthorGuo, XY (reprint author), Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China.
AbstractLeptospira interrogans peptide deformylase (LiPDF) is an important Zinc metalloprotein and plays a key role in protein synthesis of Leptospira interrogans, an ubiquitous environmental bacterium that can cause the infections of animals and humans. It is an attractive target for the design of new antibiotics since the deformyling apparently does not occur in the cytoplasm of eucaryotic cells. In this paper, we probed the protein in pH3.0 solution by X-ray absorption near-edge structure (XANES) spectroscopy. We quantitatively determined the local structure around the metal center using MXAN procedure, which is based on Multiple Scattering theory. The experimental XANES spectrum of LiPDF has been reconstructed perfectly using suitable initial structure mode, and the corresponding local structure of the active center provides structure information for understanding the PH-dependent enzymatic activity.
KeywordLiPDF metalloprotein XANES MXAN package
Subject AreaPhysics
Indexed BySCI
WOS SubjectPhysics, Nuclear ; Physics, Particles & Fields
WOS IDWOS:000243885800014
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Document Type期刊论文
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GB/T 7714
Guo XY,Chu WS,Dong YH,et al. MXAN analysis of the XANES energy region of LiPDF[J]. HIGH ENERGY PHYSICS AND NUCLEAR PHYSICS-CHINESE EDITION,2007,31(2):#REF!.
APA 郭晓云.,储旺盛.,董宇辉.,谢亚宁.,杨飞飞.,...&Wu, ZY.(2007).MXAN analysis of the XANES energy region of LiPDF.HIGH ENERGY PHYSICS AND NUCLEAR PHYSICS-CHINESE EDITION,31(2),#REF!.
MLA 郭晓云,et al."MXAN analysis of the XANES energy region of LiPDF".HIGH ENERGY PHYSICS AND NUCLEAR PHYSICS-CHINESE EDITION 31.2(2007):#REF!.
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