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Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans
Liu Y(刘颖); Gao ZQ(高增强); Liu CP(刘超培); Xu JH(徐建华); Dong YH(董宇辉); Liu, Y; Gao, ZQ; Liu, CP; Xu, JH; Li, LF; Ji, CN; Su, XD; Dong, YH
2011
发表期刊ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS
卷号67期号:2页码:#REF!
通讯作者Dong, YH (reprint author), Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing 100049, Peoples R China.
摘要Streptococcus mutans is one of the pathogenic species involved in dental caries, especially in the initiation and development stages. Here, the crystal structure of SMU.595, a putative dihydroorotate dehydrogenase ( DHOD) from S. mutans, is reported at 2.4 angstrom resolution. DHOD is a flavin mononucleotide-containing enzyme which catalyzes the oxidation of L-dihydroorotate to orotate, which is the fourth step and the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. The reductive lysine-methylation procedure was applied in order to improve the diffraction qualities of the crystals. Analysis of the S. mutans DHOD crystal structure shows that this enzyme is a class 1A DHOD and also suggests potential sites that could be exploited for the design of highly specific inhibitors using the structure-based chemotherapeutic design technique.
文章类型Article
学科领域Biochemistry & Molecular Biology; Biophysics; Crystallography
DOI10.1107/S1744309110048414
收录类别SCI
WOS类目Biochemical Research Methods ; Biochemistry & Molecular Biology ; Biophysics ; Crystallography
WOS记录号WOS:000287030600002
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226754
专题多学科研究中心
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GB/T 7714
Liu Y,Gao ZQ,Liu CP,et al. Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans[J]. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS,2011,67(2):#REF!.
APA 刘颖.,高增强.,刘超培.,徐建华.,董宇辉.,...&Dong, YH.(2011).Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans.ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS,67(2),#REF!.
MLA 刘颖,et al."Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans".ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 67.2(2011):#REF!.
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