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Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice
Yang, ST; Wang, X; Jia, G; Gu, YQ; Wang, TC; Nie, HY; Ge, CC; Wang, HF; Liu, YF; Ge CC(葛翠翠)
2008
发表期刊TOXICOLOGY LETTERS
卷号181期号:3页码:#REF!
通讯作者Wang, HF (reprint author), Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China.
摘要The biomedical application of single-walled carbon nanotubes (SWCNTs), such as drug delivery and cancer treatment, requires a clear understanding of their fate and toxicological profile after intravenous administration. In this study, the long-term accumulation and toxicity of intravenously injected SWCNTs in the main Organs (such as liver, lung and spleen) in mice were carefully studied. Although SWCNTs stayed in mice over 3 months, they showed low toxicity to mice. The long-term accumulation of SWCNTs in the main organs was evidenced by using Raman spectroscopy and TEM technique. Statistically significant changes in organ indices and serum biochemical parameters (LDH, ALT and AST) were observed. The histological observations demonstrate that slight inflammation and inflammatory cell infiltration occurred in lung, but the serum immunological indicators (CH 50 level and TNF-alpha level) remained unchanged. No apoptosis was induced in the main organs. The decreasing glutathione (GSH) level and increasing malondialdehyde (MDA) level suggest that the toxicity of SWCNTs might be due to the oxidative stress. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
文章类型Article
关键词Carbon nanotubes Intravenous administration Accumulation Toxicity Oxidative stress
学科领域Toxicology
DOI10.1016/j.toxlet.2008.07.020
收录类别SCI
WOS类目Toxicology
WOS记录号WOS:000260646100007
引用统计
被引频次:218[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226751
专题多学科研究中心
推荐引用方式
GB/T 7714
Yang, ST,Wang, X,Jia, G,et al. Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice[J]. TOXICOLOGY LETTERS,2008,181(3):#REF!.
APA Yang, ST.,Wang, X.,Jia, G.,Gu, YQ.,Wang, TC.,...&葛翠翠.(2008).Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice.TOXICOLOGY LETTERS,181(3),#REF!.
MLA Yang, ST,et al."Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice".TOXICOLOGY LETTERS 181.3(2008):#REF!.
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