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Toxicological and biological effects of nanomaterials
Chen Z(陈真); Meng H(孟幻); Xing GM(邢更妹); Chen CY(陈春英); Zhao YL(赵宇亮); Chen, Z; Meng, H; Xing, GM; Chen, CY; Zhao, YL
2007
发表期刊INTERNATIONAL JOURNAL OF NANOTECHNOLOGY
卷号4期号:1-2页码:#REF!
通讯作者Zhao, YL (reprint author), Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, IHEP, Beijing 100049, Peoples R China.
文章类型Article
摘要In this paper, we summarise the most recent findings on the toxicological and biological (including both favourable and adverse) effects of some studied nanomaterials (nanotubes, fallerene, metallofullerenes, their derivatives, and metallic nanoparticles). The dose-dependent, nanosize dependent, nano-structure dependent biological activity in particular nanotoxicity are discussed. Results show that some conventional methodology for assessing the biological activities of bulk materials may not be valid for nanomaterials even though they have the same chemical composition and are in mass basis. Nevertheless, this kind of research is still in its infancy, and many knowledge gaps exist that need to be filled by further studies. On the other hand, we show some intriguing examples that the adverse biological effects of nanomaterials can be reverse-utilised in biomedical fields. For instance, it was found that the 22 nm [Gd@C-82(OH)(22)], particles at a very low dose exhibit an anticancer rate of as high as similar to 60% in mice. Dose increase of 1 x 10(-7) mol/kg results in a 26% increment of anticancer efficiency. These nanoparticles have strong capacity to improve immunity and obstruct tumour invasion towards normal muscle cells but nearly without toxicity in vivo and in vitro. The fullerene derivatives with proper chemical modifications may help realise the dream of tumour chemotherapeutics of high-efficacy and low-toxicity.
关键词manufactured nanomaterials nanotoxicity nanobiology anticancer efficiency nanosize and nanostructure dependent nanotoxicity
学科领域Science & Technology - Other Topics; Materials Science
DOI10.1504/IJNT.2007.012323
收录类别SCI
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000245674700013
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226731
专题多学科研究中心
推荐引用方式
GB/T 7714
Chen Z,Meng H,Xing GM,et al. Toxicological and biological effects of nanomaterials[J]. INTERNATIONAL JOURNAL OF NANOTECHNOLOGY,2007,4(1-2):#REF!.
APA 陈真.,孟幻.,邢更妹.,陈春英.,赵宇亮.,...&Zhao, YL.(2007).Toxicological and biological effects of nanomaterials.INTERNATIONAL JOURNAL OF NANOTECHNOLOGY,4(1-2),#REF!.
MLA 陈真,et al."Toxicological and biological effects of nanomaterials".INTERNATIONAL JOURNAL OF NANOTECHNOLOGY 4.1-2(2007):#REF!.
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