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Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
Wang JX(王江雪); Zhou GQ(周国强); Chen CY(陈春英); Yu HW(喻宏伟); Gao YX(高愈希); Li B(李柏); Sun J(孙瑾); Li YF(李玉锋); Jiao F(焦芳); Zhao YL(赵宇亮); Chai ZF(柴之芳); Wang, JX; Zhou, GQ; Chen, CY; Yu, HW; Wang, TC; Ma, YM; Jia, G; Gao, YX; Li, B; Sun, J; Li, YF; Jiao, F; Zhao, YL; Chai, ZF
2007
Source PublicationTOXICOLOGY LETTERS
Volume168Issue:2Pages:#REF!
Corresponding AuthorChen, CY (reprint author), Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100080, Peoples R China.
SubtypeArticle
AbstractIn order to evaluate the toxicity of TiO2 particles, the acute toxicity of nano-sized TiO2 particles (25 and 80 nm) on adult mice was investigated compared with fine TiO2 particles (155 nm). Due to the low toxicity, a fixed large dose of 5 g/kg body weight of TiO2 suspensions was administrated by a single oral gavage according to the OECD procedure. In 2 weeks, TiO2 particles showed no obvious acute toxicity. However, the female mice showed high coefficients of liver in the nano-sized (25 and 80 nm) groups. The changes of serum biochemical parameters (ALT/AST, LDH) and pathology (hydropic degeneration around the central vein and the spotty necrosis of hepatocytes) of liver indicated that the hepatic injury was induced after exposure to mass different-sized TiO2 particles. In addition, the nephrotoxicity like increased BUN level and pathology change of kidneys was also observed in the experimental groups. The significant change of serum LDH and alpha-HBDH in 25 and 80 nm groups showed the myocardial damage compared with the control group. However, there are no abnormal pathology changes in the heart, lung, testicle (ovary), and spleen tissues. Biodistribution experiment showed that TiO2 mainly retained in the liver, spleen, kidneys, and lung tissues, which indicated that TiO2 particles could be transported to other tissues and organs after uptake by gastrointestinal tract. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Keywordacute toxicity fixed dose procedure titanium dioxide nanoparticles mice
Subject AreaToxicology
DOI10.1016/j.toxlet.2006.12.001
Indexed BySCI
WOS SubjectToxicology
WOS IDWOS:000244059300010
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/226697
Collection院士
实验物理中心
多学科研究中心
Recommended Citation
GB/T 7714
Wang JX,Zhou GQ,Chen CY,et al. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration[J]. TOXICOLOGY LETTERS,2007,168(2):#REF!.
APA 王江雪.,周国强.,陈春英.,喻宏伟.,高愈希.,...&Chai, ZF.(2007).Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration.TOXICOLOGY LETTERS,168(2),#REF!.
MLA 王江雪,et al."Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration".TOXICOLOGY LETTERS 168.2(2007):#REF!.
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