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Mercury speciation and mercury-binding protein study by HPLC-ICP-MS on the estimation of mercury toxicity between maternal and infant rats
Feng WY(丰伟悦); Wang M(王萌); Yuan H(袁慧); Shi JW(史俊稳); Wang B(汪冰); Zhu MT(朱墨桃); Ou YH(欧阳宏); Zhao YL(赵宇亮); Chai ZF(柴之芳); Feng, WY; Meng, W; Ming, GA; Yuan, H; Shi, JW; Bing, W; Zhu, MT; Hong, OY; Zhao, YL; Chai, ZF
2011
Source PublicationJOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
Volume26Issue:1Pages:#REF!
Corresponding AuthorFeng, WY (reprint author), Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China.
SubtypeArticle
AbstractA comparative study of methylmercury (MeHg) metabolism and its conversion into inorganic mercury (I-Hg) in organic tissues (brain, liver and kidney) and the subcellular fractions (nucleus, mitochondrion, lysosome, microsome and cytosol) of maternal and infant rats after infant in utero and lactational exposure to methylmercury was achieved by extraction preconcentration with HPLC-ICP-MS determination. The quantification of Hg-containing proteins in brain cytosol was studied by HPLC hyphenated on-line isotope dilution ICP-MS and the proteins were analyzed by SDS-PAGE and MALDI-TOF-MS. The results demonstrated that the methods could be successfully used in the study of mercury species in sub-compartments of organ cells. The study showed that the distribution patterns of MeHg and I-Hg in the levels of organs, the subcellular fractions of organs and proteins are all significantly different between mothers and their offspring, indicating their significantly different metabolism, transportation and accumulation behavior of mercury species, which may be all involved in the toxic mechanism of mercury for adults and young children.
Subject AreaChemistry; Spectroscopy
DOI10.1039/c0ja00111b
Indexed BySCI
WOS SubjectChemistry, Analytical ; Spectroscopy
WOS IDWOS:000285390600015
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/226561
Collection院士
多学科研究中心
Recommended Citation
GB/T 7714
Feng WY,Wang M,Yuan H,et al. Mercury speciation and mercury-binding protein study by HPLC-ICP-MS on the estimation of mercury toxicity between maternal and infant rats[J]. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,2011,26(1):#REF!.
APA 丰伟悦.,王萌.,袁慧.,史俊稳.,汪冰.,...&Chai, ZF.(2011).Mercury speciation and mercury-binding protein study by HPLC-ICP-MS on the estimation of mercury toxicity between maternal and infant rats.JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,26(1),#REF!.
MLA 丰伟悦,et al."Mercury speciation and mercury-binding protein study by HPLC-ICP-MS on the estimation of mercury toxicity between maternal and infant rats".JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY 26.1(2011):#REF!.
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