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Mercury speciation and mercury-binding protein study by HPLC-ICP-MS on the estimation of mercury toxicity between maternal and infant rats
Feng WY(丰伟悦); Wang M(王萌); Yuan H(袁慧); Shi JW(史俊稳); Wang B(汪冰); Zhu MT(朱墨桃); Ou YH(欧阳宏); Zhao YL(赵宇亮); Chai ZF(柴之芳); Feng, WY; Meng, W; Ming, GA; Yuan, H; Shi, JW; Bing, W; Zhu, MT; Hong, OY; Zhao, YL; Chai, ZF
刊名JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
2011
卷号26期号:1页码:#REF!
学科分类Chemistry; Spectroscopy
DOI10.1039/c0ja00111b
通讯作者Feng, WY (reprint author), Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China.
文章类型Article
英文摘要A comparative study of methylmercury (MeHg) metabolism and its conversion into inorganic mercury (I-Hg) in organic tissues (brain, liver and kidney) and the subcellular fractions (nucleus, mitochondrion, lysosome, microsome and cytosol) of maternal and infant rats after infant in utero and lactational exposure to methylmercury was achieved by extraction preconcentration with HPLC-ICP-MS determination. The quantification of Hg-containing proteins in brain cytosol was studied by HPLC hyphenated on-line isotope dilution ICP-MS and the proteins were analyzed by SDS-PAGE and MALDI-TOF-MS. The results demonstrated that the methods could be successfully used in the study of mercury species in sub-compartments of organ cells. The study showed that the distribution patterns of MeHg and I-Hg in the levels of organs, the subcellular fractions of organs and proteins are all significantly different between mothers and their offspring, indicating their significantly different metabolism, transportation and accumulation behavior of mercury species, which may be all involved in the toxic mechanism of mercury for adults and young children.
类目[WOS]Chemistry, Analytical ; Spectroscopy
收录类别SCI
WOS记录号WOS:000285390600015
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226561
专题院士_期刊论文
中国科学院高能物理研究所_多学科研究中心
推荐引用方式
GB/T 7714
Feng WY,Wang M,Yuan H,et al. Mercury speciation and mercury-binding protein study by HPLC-ICP-MS on the estimation of mercury toxicity between maternal and infant rats[J]. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,2011,26(1):#REF!.
APA 丰伟悦.,王萌.,袁慧.,史俊稳.,汪冰.,...&Chai, ZF.(2011).Mercury speciation and mercury-binding protein study by HPLC-ICP-MS on the estimation of mercury toxicity between maternal and infant rats.JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,26(1),#REF!.
MLA 丰伟悦,et al."Mercury speciation and mercury-binding protein study by HPLC-ICP-MS on the estimation of mercury toxicity between maternal and infant rats".JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY 26.1(2011):#REF!.
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