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Correlation of Alzheimer-like Tau Hyperphosphorylation and fMRI Bold Intensity
Wang, XC; Hu, ZH; Fang, ZY; Feng, Y; Yang, YH; Wang, Q; Tang, XW; Wu, YG; Wang, JZ; Tang XW(唐孝威); Wu YG(吴义根)
2004
发表期刊CURRENT ALZHEIMER RESEARCH
卷号1期号:2页码:#REF!
通讯作者Wang, JZ (reprint author), Huazhong Univ Sci & Technol, Dept Pathophysiol, Tongji Med Coll, Wuhan 430030, Peoples R China.
摘要To explore the correlation between cerebral functional alterations revealed by functional magnetic resonance imaging (fMRI) and Alzheimer disease- (AD)-like tau hyperphosphorylation, we injected bilaterally 2 mu l each of 20 mM isoproterenol (IP), a PKA activator, or of saline as a vehicle control into the hippocampus of rats. FMRI was employed to measure the intensity of BOLD signal, one of the cerebral functional markers reflecting the changes of cerebral metabolic rate of oxygen (CMRO(2)) and cerebral blood flow (CBF), in hippocampus and cortex 24 h after the operation. Immunohistochemical staining of hippocampus and cortex was carried out using phosphorylation-dependent tau antibodies. The results showed (1) that BOLD intensity in hippocampus and cortex of IP-injected rats was obviously lower than that of sham-operated group, indicating a decrease in CMRO(2) and CBF of the particular brain regions in IP-treated rats; (2) that tau was hyperphosphorylated at Ser-262/Ser-356 (12e8), Ser-396/Ser-404 (PHF-1) sites in CA1 CA2 CA3 CA4 and dentate gyrus regions of hippocampal formation and cortex area in IP group, but not in sham rats; (3) that a negative correlation between tau hyperphosphorylation and BOLD intensity in hippocampus and cortex area of IP rats was observed. The data suggested that hippocampal and cortical tau hyperphosphorylation was intimately related to BOLD intensity of the same areas. To our knowledge, this is the first report exploring the relationship between fMRI BOLD signal and AD-like tau hyperphosphorylation.
文章类型Article
关键词Alzheimer's disease tau hyperphosphorylation Isoproterenol fMRI BOLD signal CMRO(2) CBF
学科领域Neurosciences & Neurology
收录类别SCI
WOS类目Clinical Neurology ; Neurosciences
WOS记录号WOS:000207883500010
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226480
专题院士
粒子天体物理中心
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GB/T 7714
Wang, XC,Hu, ZH,Fang, ZY,et al. Correlation of Alzheimer-like Tau Hyperphosphorylation and fMRI Bold Intensity[J]. CURRENT ALZHEIMER RESEARCH,2004,1(2):#REF!.
APA Wang, XC.,Hu, ZH.,Fang, ZY.,Feng, Y.,Yang, YH.,...&吴义根.(2004).Correlation of Alzheimer-like Tau Hyperphosphorylation and fMRI Bold Intensity.CURRENT ALZHEIMER RESEARCH,1(2),#REF!.
MLA Wang, XC,et al."Correlation of Alzheimer-like Tau Hyperphosphorylation and fMRI Bold Intensity".CURRENT ALZHEIMER RESEARCH 1.2(2004):#REF!.
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