Abnormal cerebellum density in victims of rape with post-traumatic stress disorder: Voxel-based analysis of magnetic resonance imaging investigation
Sui, SG; Zhang, Y; Wu, MX; Xu, JM; Duan, L; Weng, XC; Shan, BC; Li, LJ; Dan BC(单保慈)
刊名ASIA-PACIFIC PSYCHIATRY
2010
卷号2期号:3页码:#REF!
关键词cerebellum magnetic resonance imaging neuroimaging post-traumatic stress disorder victim of rape
学科分类Psychiatry
DOI10.1111/j.1758-5872.2010.00076.x
通讯作者Li, LJ (reprint author), Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China.
文章类型Article
英文摘要Introduction: Based on early studies of non-motor function in the cerebellum and dysfunction in the cerebellum of post-traumatic stress disorder ( PTSD) patients, we presumed that the cerebellum was involved in the neuropathology of cognitive and emotional processing of PTSD patients, while the density of some sub-areas of the cerebellum of PTSD patients was most likely abnormal. Methods: Eleven female victims of rape with PTSD and 12 age-matched female normal controls received 1.5 T 3D magnetic resonance imaging (MRI) scan. The scans were then analyzed using the voxel-based morphometry 2 ( VBM2) toolbox. Results: Victims of rape with PTSD showed increased cerebellum density on the left side compared with normal controls (P<0.001), especially in the pyramis ( x = -9, y = -72, z = -36; k = 519; t = 4.70), uvula ( x = -4, y = -66, z = -35; k = 256; t = 4.02), declive ( x = -6, y = -69, z = -30; k = 213; t = 3.84) and nodule ( x = -4, y = -63, z = -31; k = 147; t = 3.93). In addition, compared with normal controls, the PTSD group showed significant differences in gray matter density of other brain areas, including the frontal lobe, parietal lobe, occipital lobe (P<0.001), insula, posterior cingulate, amygdala and hippocampus (P<0.005). Discussion: These finding suggest that the cerebellum may be involved in the neuropathology and functional compensation in the neurocircuitry of PTSD.
类目[WOS]Psychiatry
收录类别SCI
WOS记录号WOS:000282375900075
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226369
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
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Sui, SG,Zhang, Y,Wu, MX,et al. Abnormal cerebellum density in victims of rape with post-traumatic stress disorder: Voxel-based analysis of magnetic resonance imaging investigation[J]. ASIA-PACIFIC PSYCHIATRY,2010,2(3):#REF!.
APA Sui, SG.,Zhang, Y.,Wu, MX.,Xu, JM.,Duan, L.,...&单保慈.(2010).Abnormal cerebellum density in victims of rape with post-traumatic stress disorder: Voxel-based analysis of magnetic resonance imaging investigation.ASIA-PACIFIC PSYCHIATRY,2(3),#REF!.
MLA Sui, SG,et al."Abnormal cerebellum density in victims of rape with post-traumatic stress disorder: Voxel-based analysis of magnetic resonance imaging investigation".ASIA-PACIFIC PSYCHIATRY 2.3(2010):#REF!.
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