Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex
Hao, YH; Yan Q(闫强); Yan, Q; Liu, HH; Xu, L; Xue, ZM; Song, XQ; Kaneko, Y; Jiang, TZ; Liu, ZN; Shan, BC; Dan BC(单保慈)
刊名SCHIZOPHRENIA RESEARCH
2009
卷号114期号:1-3页码:#REF!
关键词Schizophrenia Healthy siblings Diffusion tensor imaging Fractional anisotropy
学科分类Psychiatry
DOI10.1016/j.schres.2009.07.001
通讯作者Shan, BC (reprint author), Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Anal, Beijing 100049, Peoples R China.
文章类型Article
英文摘要Healthy siblings of schizophrenia patients have an almost 9-fold higher risk for developing the illness than the general population. Disruption of white matter (WM) integrity as indicated by reduced fractional anisotropy (FA) derived from diffusion tensor imaging (DTI), is believed to be the key substrate of schizophrenia. However, it remains unclear whether schizophrenia patients and their healthy siblings share a specific pattern of disruption of WM integrity that may be related to the disease risk. The objective of this study is to determine whether a specific brain regional pattern of disruption of WM integrity is shared by schizophrenia patients and their healthy siblings. We investigated brain white matter abnormalities by voxel-based analysis of white matter FA data acquired from diffusion tensor imaging in 34 pairs of schizophrenia patients and their healthy siblings, as well as in 32 healthy controls. Both schizophrenia patients and their healthy siblings showed reduced white matter FA in the left prefrontal cortex and the hippocampus in comparison to healthy controls, without significant difference between patients and siblings. In marked contrast, only schizophrenia patients exhibited reduced white matter FA in the left anterior cingulate cortex in comparison to both siblings and controls, without significant difference between siblings and controls. Thus, schizophrenia patients and their healthy siblings share disruption of WM integrity in the left prefrontal cortex and the hippocampus that may be related to higher risk of healthy siblings to develop schizophrenia, which may be eventually attributed to additional disruption of WM integrity in the left anterior cingulate cortex. (C) 2009 Elsevier B.V. All rights reserved.
类目[WOS]Psychiatry
收录类别SCI
WOS记录号WOS:000270758700018
引用统计
被引频次:66[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226357
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
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Hao, YH,Yan Q,Yan, Q,et al. Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex[J]. SCHIZOPHRENIA RESEARCH,2009,114(1-3):#REF!.
APA Hao, YH.,闫强.,Yan, Q.,Liu, HH.,Xu, L.,...&单保慈.(2009).Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex.SCHIZOPHRENIA RESEARCH,114(1-3),#REF!.
MLA Hao, YH,et al."Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex".SCHIZOPHRENIA RESEARCH 114.1-3(2009):#REF!.
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