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Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study
Hui, JJ; Zhang, ZJ; Liu, SS; Xi, GJ; Zhang, XR; Teng, GJ; Chan, KC; Wu, EX; Nie, BB; Shan, BC; Li, LJ; Reynolds, GP; Nie BB(聂彬彬); Dan BC(单保慈)
2011
发表期刊BEHAVIOURAL BRAIN RESEARCH
卷号217期号:1页码:#REF!
通讯作者Zhang, ZJ (reprint author), Southeast Univ, Dept Neurol, Affiliated ZhongDa Hosp, 87 DingliaQiao Rd, Nanjing, Jiangsu, Peoples R China.
文章类型Article
摘要Exposure to early life stress results in behavioural changes, and these dysfunctions may persist throughout adulthood. In this study, we investigated whether hippocampus volume and neurochemical changes were involved in the appearance of these effects in the maternal separation (MS) animal model using the noninvasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Sprague-Dawley rats exposed to MS for 180 min from postnatal days (PND) 2-14 demonstrated decreased sucrose preference, increased immobility in the forced swimming test (FST), and impaired memory in the Morris water maze in adulthood. Environmental enrichment (EE) (PND 21-60) could ameliorate the effects of MS on sucrose preference and learning and memory but not on immobility in the FST. In addition, EE significantly increased N-acetylaspartate (NAA) of MS animals. However, we did not find an effect of MS or EE on hippocampal volume. These results indicate the involvement of hippocampal neurochemistry in the behavioural changes that result from early stressful life events and their modification by post-weaning EE. Thus changes in NAA, as a measure of neuronal integrity, appear to be a sensitive correlate of these behavioural effects. (C) 2010 Elsevier B.V. All rights reserved.
关键词Hippocampus Maternal separation Environmental enrichment Magnetic resonance imaging Magnetic resonance spectroscopy Rat
学科领域Behavioral Sciences; Neurosciences & Neurology
DOI10.1016/j.bbr.2010.10.014
收录类别SCI
WOS类目Behavioral Sciences ; Neurosciences
WOS记录号WOS:000286539700018
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226307
专题多学科研究中心
核技术应用研究中心
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Hui, JJ,Zhang, ZJ,Liu, SS,et al. Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study[J]. BEHAVIOURAL BRAIN RESEARCH,2011,217(1):#REF!.
APA Hui, JJ.,Zhang, ZJ.,Liu, SS.,Xi, GJ.,Zhang, XR.,...&单保慈.(2011).Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study.BEHAVIOURAL BRAIN RESEARCH,217(1),#REF!.
MLA Hui, JJ,et al."Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study".BEHAVIOURAL BRAIN RESEARCH 217.1(2011):#REF!.
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