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Comparison of the chromium distribution in organs and subcellular fractions of normal and diabetic rats by using enriched stable isotope Cr-50 tracer technique
Feng WY(丰伟悦); Ding WJ(丁万见); Qian QF(钱琴芳); Chai ZF(柴之芳); Feng, WY; Ding, WJ; Qian, GF; Chai, ZF
刊名BIOLOGICAL TRACE ELEMENT RESEARCH
1999
卷号25965页码:#REF!
关键词Enriched stable isotope Cr-50(III) subcellular distribution diabetes INAA
学科分类Biochemistry & Molecular Biology; Endocrinology & Metabolism
DOI10.1007/BF02784198
通讯作者Feng, WY (reprint author), Chinese Acad Sci, Inst High Energy Phys, POB 2732, Beijing 100080, Peoples R China.
文章类型Article; Proceedings Paper
英文摘要The enriched stable isotope Cr-50(III) tracer technique combined with neutron activation analysis was used to examine the intracellular distribution of Cr(III) in the liver, pancreas, testes, and kidney homogenates of both normal and diabetic rats. Our new results showed that the nucleic fraction has the highest Cr concentration in the Liver cell of both normal and diabetic rats. The diabetic rats retain more Cr in the mitochondrial and lysosomal fractions of liver homogenate than the normal. This is likely an indication of chromium participating in the glucose or lipid metabolism to compensate the low level of insulin in the body of diabetic rats. The concentrations of Cr in the subcellular fractions of pancreas, testes, and kidney in the normal rats are higher than those in the diabetic rats, which favor the hypothesis that Cr(LII) plays its biological function via interaction with the insulin-sensitive tissues or enhancement of the sensitivity of the insulin receptor.
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
收录类别SCI
WOS记录号WOS:000084610100015
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226300
专题院士_期刊论文
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GB/T 7714
Feng WY,Ding WJ,Qian QF,et al. Comparison of the chromium distribution in organs and subcellular fractions of normal and diabetic rats by using enriched stable isotope Cr-50 tracer technique[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,1999,25965:#REF!.
APA 丰伟悦.,丁万见.,钱琴芳.,柴之芳.,Feng, WY.,...&Chai, ZF.(1999).Comparison of the chromium distribution in organs and subcellular fractions of normal and diabetic rats by using enriched stable isotope Cr-50 tracer technique.BIOLOGICAL TRACE ELEMENT RESEARCH,25965,#REF!.
MLA 丰伟悦,et al."Comparison of the chromium distribution in organs and subcellular fractions of normal and diabetic rats by using enriched stable isotope Cr-50 tracer technique".BIOLOGICAL TRACE ELEMENT RESEARCH 25965(1999):#REF!.
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