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Subcellular localization of several heavy metals of Hg, Cd and Pb in human liver
Chen CY(陈春英); Zhang PQ(章佩群); Chai ZF(柴之芳); Chen, CY; Zhang, PQ; Chai, ZF
2005
发表期刊CHINESE SCIENCE BULLETIN
卷号50期号:2页码:#REF!
通讯作者Chen, CY (reprint author), Chinese Acad Sci, Key Lab Nucl Analyt Tech, Beijing 100039, Peoples R China.
摘要Liver, as an important metabolic and detoxicological organ of human body, can be used as a good bioindicator for evaluating body burden of environmental pollutants. Its elemental contents and their chemical forms are closely related to the status of human health and disease. In this paper, the liver samples collected from normal subjects were separated to different subcellular fractions of nuclei, mitochondria, lysosome, microsome and cytosol by differential centrifugation. Then their concentrations of heavy metals of As, Pb, Cd, and Hg were determined by atomic absorption and atomic fluorescent spectroscopy. Our results show no significant difference with literature ones when comparing their gross concentrations. In the case of their subcellular distribution, the Hg concentrations are higher in mitochondrial, microsomal and cytosolic fractions; the Cd concentrations are higher in cytosolic and mitochondrial fractions, while As highest in nuclear fraction. The highest concentration of Pb is found in microsomal fraction with similarity to Fe. Mercury in liver is mainly in the form of inorganic, and methylmercury ranged from 9% to 50% with the average value of 20.9% +/- 13.3%. These results indicate that the cellular distribution and the accumulated target organelles are quite different among these heavy metals, which suggest their various pathways and toxic mechanism in vivo.
文章类型Article
关键词human liver subcellular fraction distribution heavy metals methylmercury
学科领域Science & Technology - Other Topics
DOI10.1360/03wb0223
收录类别SCI
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000228262700004
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226250
专题院士
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GB/T 7714
Chen CY,Zhang PQ,Chai ZF,et al. Subcellular localization of several heavy metals of Hg, Cd and Pb in human liver[J]. CHINESE SCIENCE BULLETIN,2005,50(2):#REF!.
APA 陈春英,章佩群,柴之芳,Chen, CY,Zhang, PQ,&Chai, ZF.(2005).Subcellular localization of several heavy metals of Hg, Cd and Pb in human liver.CHINESE SCIENCE BULLETIN,50(2),#REF!.
MLA 陈春英,et al."Subcellular localization of several heavy metals of Hg, Cd and Pb in human liver".CHINESE SCIENCE BULLETIN 50.2(2005):#REF!.
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