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Neurotoxicological consequence of long-term exposure to lanthanum
Feng LX(冯流星); Xiao HQ(肖海清); He X(何潇); Li ZJ(李子杰); Li FL(李福亮); Liu NQ(刘年庆); Zhao YL(赵宇亮); Huang YY(黄宇营); Zhang ZY(张智勇); Chai ZF(柴之芳); Feng, LX; Xiao, HQ; He, X; Li, ZJ; Li, FL; Liu, NQ; Zhao, YL; Huang, YY; Zhang, ZY; Chai, ZF
Corresponding AuthorZhang, ZY (reprint author), Chinese Acad Sci, Key Lab Nucl Analyt Tech, POB 918, Beijing 100049, Peoples R China.
AbstractLanthanides, because of their diversified physical and chemical effects, have been widely used in a number of fields. As a result, more and more lanthanides are entering into the environment and eventually accumulated in human body. Recently, a new medicine, lanthanum carbonate (Fosrenol), has been used to treat chronic renal failure (CRF), and the dosage is much higher than the daily intake of lanthanides. However, the effects of lanthanides on human body, especially on the central nervous system, are still unclear. The aim of this study was to determine whether long-term lanthanum exposure results in persistent alternations in nervous system function. Wistar rats were exposed to lanthanum chloride (LaCl3) through oral administration at 0, 0.1, 2 and 40 mg/kg concentration from 4 weeks through 6 months of a e. Morris water maze test showed that lanthanum exposure at 40 mg/kg could significantly impair the behavioral performance. To fully investigate the neurotoxicological consequence of lanthanum exposure, brain elemental distributions and neurochemicals were also investigated. The distributions of brain elements such as Ca, Fe and Zn were significantly altered after lanthanum exposure. Moreover, 40 mg/kg LaCl3 significantly inhibited the activity of Ca2+-ATPase; the function of the central cholinergic system was also noticeably disturbed and the contents of some monoamines neurotransmitters were significantly decreased. These findings indicate that chronic exposure to lanthanum could possibly impair the learning ability and this deficit may be possibly attributed to the disturbance of the homeostasis of trace elements, enzymes and neurotransmitter systems in brain. Therefore, the application of lanthanide, especially in pharmacology, should be cautious. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Keywordlanthanum toxicology brain element neurotransmitter
Subject AreaToxicology
Indexed BySCI
WOS SubjectToxicology
WOS IDWOS:000239185100002
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Document Type期刊论文
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GB/T 7714
Feng LX,Xiao HQ,He X,et al. Neurotoxicological consequence of long-term exposure to lanthanum[J]. TOXICOLOGY LETTERS,2006,165(2):#REF!.
APA 冯流星.,肖海清.,何潇.,李子杰.,李福亮.,...&Chai, ZF.(2006).Neurotoxicological consequence of long-term exposure to lanthanum.TOXICOLOGY LETTERS,165(2),#REF!.
MLA 冯流星,et al."Neurotoxicological consequence of long-term exposure to lanthanum".TOXICOLOGY LETTERS 165.2(2006):#REF!.
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