IHEP OpenIR  > 院士  > 期刊论文
Neurotoxicological consequence of long-term exposure to lanthanum
Feng LX(冯流星); Xiao HQ(肖海清); He X(何潇); Li ZJ(李子杰); Li FL(李福亮); Liu NQ(刘年庆); Zhao YL(赵宇亮); Huang YY(黄宇营); Zhang ZY(张智勇); Chai ZF(柴之芳); Feng, LX; Xiao, HQ; He, X; Li, ZJ; Li, FL; Liu, NQ; Zhao, YL; Huang, YY; Zhang, ZY; Chai, ZF
刊名TOXICOLOGY LETTERS
2006
卷号165期号:2页码:#REF!
关键词lanthanum toxicology brain element neurotransmitter
学科分类Toxicology
DOI10.1016/j.toxlet.2006.02.003
通讯作者Zhang, ZY (reprint author), Chinese Acad Sci, Key Lab Nucl Analyt Tech, POB 918, Beijing 100049, Peoples R China.
文章类型Article
英文摘要Lanthanides, because of their diversified physical and chemical effects, have been widely used in a number of fields. As a result, more and more lanthanides are entering into the environment and eventually accumulated in human body. Recently, a new medicine, lanthanum carbonate (Fosrenol), has been used to treat chronic renal failure (CRF), and the dosage is much higher than the daily intake of lanthanides. However, the effects of lanthanides on human body, especially on the central nervous system, are still unclear. The aim of this study was to determine whether long-term lanthanum exposure results in persistent alternations in nervous system function. Wistar rats were exposed to lanthanum chloride (LaCl3) through oral administration at 0, 0.1, 2 and 40 mg/kg concentration from 4 weeks through 6 months of a e. Morris water maze test showed that lanthanum exposure at 40 mg/kg could significantly impair the behavioral performance. To fully investigate the neurotoxicological consequence of lanthanum exposure, brain elemental distributions and neurochemicals were also investigated. The distributions of brain elements such as Ca, Fe and Zn were significantly altered after lanthanum exposure. Moreover, 40 mg/kg LaCl3 significantly inhibited the activity of Ca2+-ATPase; the function of the central cholinergic system was also noticeably disturbed and the contents of some monoamines neurotransmitters were significantly decreased. These findings indicate that chronic exposure to lanthanum could possibly impair the learning ability and this deficit may be possibly attributed to the disturbance of the homeostasis of trace elements, enzymes and neurotransmitter systems in brain. Therefore, the application of lanthanide, especially in pharmacology, should be cautious. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
类目[WOS]Toxicology
收录类别SCI
WOS记录号WOS:000239185100002
引用统计
被引频次:78[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226236
专题院士_期刊论文
中国科学院高能物理研究所_多学科研究中心
推荐引用方式
GB/T 7714
Feng LX,Xiao HQ,He X,et al. Neurotoxicological consequence of long-term exposure to lanthanum[J]. TOXICOLOGY LETTERS,2006,165(2):#REF!.
APA 冯流星.,肖海清.,何潇.,李子杰.,李福亮.,...&Chai, ZF.(2006).Neurotoxicological consequence of long-term exposure to lanthanum.TOXICOLOGY LETTERS,165(2),#REF!.
MLA 冯流星,et al."Neurotoxicological consequence of long-term exposure to lanthanum".TOXICOLOGY LETTERS 165.2(2006):#REF!.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
1276.pdf(570KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[冯流星]的文章
[肖海清]的文章
[何潇]的文章
百度学术
百度学术中相似的文章
[冯流星]的文章
[肖海清]的文章
[何潇]的文章
必应学术
必应学术中相似的文章
[冯流星]的文章
[肖海清]的文章
[何潇]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 1276.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。