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Interaction Between Nano-Anatase TiO2 and Liver DNA from Mice In Vivo
Li, N; Ma, LL; Wang, J; Zheng, L; Liu, J; Duan, YM; Liu, HT; Zhao, XY; Wang, SS; Wang, H; Hong, FS; Xie, YN; Xie YN(谢亚宁)
2010
发表期刊NANOSCALE RESEARCH LETTERS
卷号5期号:1页码:#REF!
通讯作者Hong, FS (reprint author), Soochow Univ, Coll Med, Suzhou 215123, Peoples R China.
文章类型Article
摘要Nano-TiO2 was shown to cause various toxic effects in both rats and mice; however, the molecular mechanism by which TiO2 exerts its toxicity is poorly understood. In this report, an interaction of nano-anatase TiO2 with liver DNA from ICR mice was systematically studied in vivo using ICP-MS, various spectral methods and gel electrophoresis. We found that the liver weights of the mice treated with higher amounts of nano-anatase TiO2 were significantly increased. Nano-anatase TiO2 could be accumulated in liver DNA by inserting itself into DNA base pairs or binding to DNA nucleotide that bound with three oxygen or nitrogen atoms and two phosphorous atoms of DNA with the Ti-O(N) and Ti-P bond lengths of 1.87 and 2.38 , respectively, and alter the conformation of DNA. And gel electrophoresis showed that higher dose of nano-anatase TiO2 could cause liver DNA cleavage in mice.
关键词Nano-anatase TiO2 Mice DNA Binding information DNA cleavage
学科领域Science & Technology - Other Topics; Materials Science; Physics
DOI10.1007/s11671-009-9451-2
收录类别SCI
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000272916400017
引用统计
被引频次:64[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226204
专题多学科研究中心
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GB/T 7714
Li, N,Ma, LL,Wang, J,et al. Interaction Between Nano-Anatase TiO2 and Liver DNA from Mice In Vivo[J]. NANOSCALE RESEARCH LETTERS,2010,5(1):#REF!.
APA Li, N.,Ma, LL.,Wang, J.,Zheng, L.,Liu, J.,...&谢亚宁.(2010).Interaction Between Nano-Anatase TiO2 and Liver DNA from Mice In Vivo.NANOSCALE RESEARCH LETTERS,5(1),#REF!.
MLA Li, N,et al."Interaction Between Nano-Anatase TiO2 and Liver DNA from Mice In Vivo".NANOSCALE RESEARCH LETTERS 5.1(2010):#REF!.
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