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Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats
Zhu MT(朱墨桃); Feng WY(丰伟悦); Wang B(汪冰); Wang M(王萌); Wang M(王萌); Ou YH(欧阳宏); Zhao YL(赵宇亮); Chai ZF(柴之芳); Zhu, MT; Feng, WY; Wang, B; Wang, TC; Gu, YQ; Wang, M; Wang, Y; Ouyang, H; Zhao, YL; Chai, ZF
2008
发表期刊TOXICOLOGY
卷号247期号:2-3页码:#REF!
通讯作者Feng, WY (reprint author), Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Efffects Nanomat & Nanosafety, Beijing 100049, Peoples R China.
文章类型Article
摘要Ferric oxide (Fe(2)O(3)) nanoparticles are of considerable interest for application in nanotechnology related fields. However, as iron being a highly redox-active transition metal, the safety of iron nanomaterials need to be further studied. In this study, the size, dose and time dependent of Fe(2)O(3) nanoparticle on pulmonary and coagulation system have been studied after intratracheal instillation. The Fe(2)O(3) nanoparticles with mean diameters of 22 and 280 nm, respectively, were intratracheally instilled to male Sprague Dawley rats at low (0.8 mg/kg bw) and high (20 mg/kg bw) doses. The toxic effects were monitored in the post-instilled 1, 7 and 30 days. Our results showed that the Fe(2)O(3) nanoparticle exposure could induce oxidative stress in lung. Alveolar macrophage (AM) over-loading of phagocytosed nanoparticle by high dose treatment had occurred, while the non-phagocytosed particles were found entering into alveolar epithelial in day 1 after exposure. Several inflammatory reactions including inflammatory and immune cells increase, clinical pathological changes: follicular hyperplasia, protein effusion, pulmonary capillary vessel hyperaemia and alveolar lipoproteinosis in lung were observed. The sustain burden of particles in AM and epithelium cells has caused lung emphysema and pro-sign of lung fibrosis. At the post-instilled day 30, the typical coagulation parameters, prothrombin time (PT) and activated partial thromboplastin time (APTT) in blood of low dose 22 nm-Fe(2)O(3) treated rats were significantly longer than the controls. We concluded that both of the two-sized Fe(2)O(3) particle intratracheal exposure could induce lung injury. Comparing with the submicron-sized Fe(2)O(3) particle, the nano-sized Fe(2)O(3) particle may increase microvascular permeability and cell lysis in lung epitheliums and disturb blood coagulation parameters significantly. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
关键词ferric oxide nanoparticle pulmonary response coagulatory disturbance intratracheal instillation
学科领域Pharmacology & Pharmacy; Toxicology
DOI10.1016/j.tox.2008.02.011
收录类别SCI
WOS类目Pharmacology & Pharmacy ; Toxicology
WOS记录号WOS:000256208400005
引用统计
被引频次:157[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226159
专题院士
多学科研究中心
推荐引用方式
GB/T 7714
Zhu MT,Feng WY,Wang B,et al. Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats[J]. TOXICOLOGY,2008,247(2-3):#REF!.
APA 朱墨桃.,丰伟悦.,汪冰.,王萌.,王萌.,...&Chai, ZF.(2008).Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats.TOXICOLOGY,247(2-3),#REF!.
MLA 朱墨桃,et al."Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats".TOXICOLOGY 247.2-3(2008):#REF!.
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