IHEP OpenIR  > 多学科研究中心
Ultrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles
Meng H(孟幻); Chen Z(陈真); Xing GM(邢更妹); Yuan H(袁慧); Chen CY(陈春英); Zhao F(赵峰); Zhang CC(张程程); Zhao YL(赵宇亮); Meng, H; Chen, Z; Xing, GM; Yuan, H; Chen, CY; Zhao, F; Zhang, CC; Zhao, YL
2007
发表期刊TOXICOLOGY LETTERS
卷号175期号:1-3页码:#REF!
通讯作者Xing, GM (reprint author), Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China.
摘要Recently, studies on the biological effects of nanomaterials show signs that some of the manufactured nanoparticles exhibit unexpected toxicity to living organisms. It has previously been reported that the copper particles possess size-depended toxicity. In this paper, we propose that the ultrahigh chemical reactivity of nano-copper results in the specific nanotoxicity which is fully proved by in vitro and in vivo experiment. Using chemical kinetics study (in vitro) and blood gas and plasma electrolytes analysis (in vivo), we found that high reactivity cause the big toxicological difference between small size (23.5 nm) and big size (17 mu m). The result is also consistent with biochemistry assay, pathological examination and copper content measurement in renal tissue in vivo. For chemical reactive nanoparticles, metallic nano-copper for instance, both the particles themselves and the resulting product (copper ion) should be fully explored. The nano-copper particles may not compromise the mice directly, however, they lead to the accumulation of excessive alkalescent substance and heavy metal ions (copper ions) culminating the metabolic alkalosis and copper ion overload. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
文章类型Article
关键词nanotoxicity ultrahigh reactivity copper metabolic alkalosis copper ion overload
学科领域Toxicology
DOI10.1016/j.toxlet.2007.09.015
收录类别SCI
WOS类目Toxicology
WOS记录号WOS:000251696900012
引用统计
被引频次:132[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/226158
专题多学科研究中心
推荐引用方式
GB/T 7714
Meng H,Chen Z,Xing GM,et al. Ultrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles[J]. TOXICOLOGY LETTERS,2007,175(1-3):#REF!.
APA 孟幻.,陈真.,邢更妹.,袁慧.,陈春英.,...&Zhao, YL.(2007).Ultrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles.TOXICOLOGY LETTERS,175(1-3),#REF!.
MLA 孟幻,et al."Ultrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles".TOXICOLOGY LETTERS 175.1-3(2007):#REF!.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
1178.pdf(926KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[孟幻]的文章
[陈真]的文章
[邢更妹]的文章
百度学术
百度学术中相似的文章
[孟幻]的文章
[陈真]的文章
[邢更妹]的文章
必应学术
必应学术中相似的文章
[孟幻]的文章
[陈真]的文章
[邢更妹]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 1178.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。