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Ytterbium and trace element distribution in brain and organic tissues of offspring rats after prenatal and postnatal exposure to ytterbium
Feng LX(冯流星); He X(何潇); Xiao HQ(肖海清); Li ZJ(李子杰); Li FL(李福亮); Liu NQ(刘年庆); Chai ZF(柴之芳); Zhao YL(赵宇亮); Zhang ZY(张智勇); Feng, LX; He, X; Xiao, HQ; Li, ZJ; Li, FL; Liu, NQ; Chai, ZF; Zhao, YL; Zhang, ZY
2007
Source PublicationBIOLOGICAL TRACE ELEMENT RESEARCH
Volume117Issue:1-3Pages:#REF!
Corresponding AuthorZhang, ZY (reprint author), Chinese Acad Sci, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China.
SubtypeArticle
AbstractLanthanides, because of their diversified physical and chemical effects, have been widely used in a number of fields. As a result, more and more lanthanides are entering the environment and eventually accumulating in the human body. Previous studies indicate that the impact of lanthanides on brain function cannot be neglected. Although neurological studies of trace elements are of paramount importance, up to now, little data are provided regarding the status of micronutritional elements in rats after prenatal and long-term exposure to lanthanide. The aim of this study is to determine the ytterbium (Yb) and trace elements distribution in brain and organic tissues of offspring rats after prenatal and long-term exposure to Yb. Wistar rats were exposed to Yb through oral administration at 0, 0.1, 2, and 40 mg Yb/kg concentrations from gestation day 0 through 5 mo of age. Concentrations of Yb and other elements (Mg, Ca, Fe, Cu, Mn, and Zn) in the serum, liver, femur, and brain regions (cerebral cortex, hippocampus, cerebellum, and the rest) of offspring rats at the age of 0 d, 25 d, and 5 mo were analyzed by inductively coupled plasma-mass spectrometry. The accumulation of Yb in the brain, liver, and femur is observed; moreover, the levels of Fe, Cu, Mn, Zn, Ca, and Mg in the brain and organic tissues of offspring rats are also altered after Yb exposure. This disturbance of the homeostasis of trace elements might induce adverse effects on normal physiological functions of the brain and other organs.
Keywordytterbium toxicology trace elements
Subject AreaBiochemistry & Molecular Biology; Endocrinology & Metabolism
DOI10.1007/BF02698086
Indexed BySCI
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000248847400009
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/226067
Collection院士
多学科研究中心
Recommended Citation
GB/T 7714
Feng LX,He X,Xiao HQ,et al. Ytterbium and trace element distribution in brain and organic tissues of offspring rats after prenatal and postnatal exposure to ytterbium[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2007,117(1-3):#REF!.
APA 冯流星.,何潇.,肖海清.,李子杰.,李福亮.,...&Zhang, ZY.(2007).Ytterbium and trace element distribution in brain and organic tissues of offspring rats after prenatal and postnatal exposure to ytterbium.BIOLOGICAL TRACE ELEMENT RESEARCH,117(1-3),#REF!.
MLA 冯流星,et al."Ytterbium and trace element distribution in brain and organic tissues of offspring rats after prenatal and postnatal exposure to ytterbium".BIOLOGICAL TRACE ELEMENT RESEARCH 117.1-3(2007):#REF!.
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