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Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases
Wang JX(王江雪); Chen CY(陈春英); Liu Y(刘颖); Jiao F(焦芳); Li W(李炜); Lao F(劳芳); Li YF(李玉锋); Li B(李柏); Ge CC(葛翠翠); Zhou GQ(周国强); Gao YX(高愈希); Zhao YL(赵宇亮); Chai ZF(柴之芳); Wang, JX; Chen, CY; Liu, Y; Jiao, F; Li, W; Lao, F; Li, YF; Li, B; Ge, CC; Zhou, GQ; Gao, YX; Zhao, YL; Chai, ZF
刊名TOXICOLOGY LETTERS
2008
卷号183期号:1-3页码:#REF!
关键词TiO2 nanomaterials Neurotoxicology Redox status Protein oxidation Lipid peroxidation GFAP expression
学科分类Toxicology
DOI10.1016/j.toxlet.2008.10.001
通讯作者Chen, CY (reprint author), Chinese Acad Sci, NCNST, Lab Bioenvironm Effects Nanomat & Nanosafety, 11 1st North St, Beijing 100049, Peoples R China.
文章类型Article
英文摘要Nanoscale titanium dioxide (TiO2) is massively produced and widely used in living environment, which hence make the potential risk to human health. Central nervous system (CNS) is the potential susceptible target of inhaled nanoparticles, but the studies on this aspect are limited so far. We report the accumulation and toxicity results in vivo of two crystalline phases of TiO2 nanoparticles (80 nm, rutile and 155 nm, anatase; purity > 99%). The female mice were intranasally instilled with 500 mu g of TiO2 nanoparticles suspension every other day for 30 days. Synchrotron radiation X-ray fluorescence analysis (SRXRF) and inductively coupled plasma mass spectrometry (ICP-MS) were used to determine the contents of titanium in murine brain. Then, the pathological examination of brain tissue, oxidative stress-mediated responses, and levels of neurochemicals in the brain of exposed mice were also analyzed. The obvious morphological changes of hippocampal neurons and increased GFAP-positive astrocytes in the CA4 region were observed, which were in good agreements with higher Ti contents in the hippocampus region. Oxidative stress occurred obviously in whole brain of exposed mice such as lipid peroxidation, protein oxidation and increased activities of catalase, as well as the excessive release of glutamic acid and nitric oxide. These findings indicate anatase TiO2 nanoparticles exhibited higher concern on some tested biological effects. To summarize, results provided the preliminary evidence that nasal instilled TiO2 nanoparticles could be translocated into the central nervous system and cause potential lesion of brain, and the hippocampus would be the main target within brain. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
类目[WOS]Toxicology
收录类别SCI
WOS记录号WOS:000262053000010
引用统计
被引频次:199[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225945
专题院士_期刊论文
推荐引用方式
GB/T 7714
Wang JX,Chen CY,Liu Y,et al. Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases[J]. TOXICOLOGY LETTERS,2008,183(1-3):#REF!.
APA 王江雪.,陈春英.,刘颖.,焦芳.,李炜.,...&Chai, ZF.(2008).Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases.TOXICOLOGY LETTERS,183(1-3),#REF!.
MLA 王江雪,et al."Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases".TOXICOLOGY LETTERS 183.1-3(2008):#REF!.
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