IHEP OpenIR  > 院士
Microtranslocation of trace element in the olfactory bulb of mice after intranasal instillation of fine oxide particle by synchrotron radiation x-ray fluorescence
其他题名鼻腔滴入Fe2O3细颗粒在小鼠嗅球中的微区分布及对其他微量元素的影响
Wan DY(万冬云); He Q(何庆); Jia QJ(贾全杰); Zhang RG(张仁刚); Zhang H(张辉); Wang BY(王宝义); Wei L(魏龙); Wang, B; Feng, WY; Wang, M; Shi, JW; Zhang, F; Ouyang, H; Zhao, YL; Chai, ZF; Huang, YY; Xie, YN
2005
发表期刊HIGH ENERGY PHYSICS AND NUCLEAR PHYSICS-CHINESE EDITION
卷号29页码:#REF!
通讯作者Wang, B (reprint author), CAS, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China.
摘要The contents and micro distribution of iron and other trace elements in the olfactory bulb after intranasal instillation were measured by synchrotron radiation X-ray fluorescence analysis (SRXRF). The mice were intranasally instilled of fine iron oxide particles (60-200nm) at a dose of 40mg/kg b ody weight. Two weeks later, the content of iron in the olfactory bulb increased 20% compared with the control. The elevated iron was predominately concerned in the olfactory nerve (ON), granular layer (Gl) and anterior olfactory nucleus, external part (AOE), which indicated that fine iron oxide was transported to Cl via primary olfactory nerve and further translocated in AOE via secondary olfactory nerve. Moreover, in the experiment group, the levels of Ca increased 12% and Zn decreased 17%. Similarly to Fe, the higher Ca concentration was dominantly accumulated in the ON and Gl layers as well. Although the average Cu content in the control and experimental group was similar, the distribution of Cu was obviously changed due to the exposure of fine Fe2O3 particles. In the control, Cu was primarily concerned in anterior olfactory nucleus, lateral part (AOL), AOE, accessory olfactory bulb (AOB) and granule cell layer of the accessory olfactory bulb (GrA), while the Cu content in the experimental group was significantly higher in the ON, Gl and EPI layers. In conclusion, the changes of Fe, Ca, Zn, Cu levels must be, to some extent, correlate with the oxidative stress and neurodegenerative diseases.
文章类型Article
关键词fine particle iron oxide SRXRF olfactory bulb microtranslocation of trace element
学科领域Physics
收录类别SCI
WOS类目Physics, Nuclear ; Physics, Particles & Fields
WOS记录号WOS:000234206900019
引用统计
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225937
专题院士
推荐引用方式
GB/T 7714
Wan DY,He Q,Jia QJ,et al. Microtranslocation of trace element in the olfactory bulb of mice after intranasal instillation of fine oxide particle by synchrotron radiation x-ray fluorescence[J]. HIGH ENERGY PHYSICS AND NUCLEAR PHYSICS-CHINESE EDITION,2005,29:#REF!.
APA 万冬云.,何庆.,贾全杰.,张仁刚.,张辉.,...&Xie, YN.(2005).Microtranslocation of trace element in the olfactory bulb of mice after intranasal instillation of fine oxide particle by synchrotron radiation x-ray fluorescence.HIGH ENERGY PHYSICS AND NUCLEAR PHYSICS-CHINESE EDITION,29,#REF!.
MLA 万冬云,et al."Microtranslocation of trace element in the olfactory bulb of mice after intranasal instillation of fine oxide particle by synchrotron radiation x-ray fluorescence".HIGH ENERGY PHYSICS AND NUCLEAR PHYSICS-CHINESE EDITION 29(2005):#REF!.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
876.pdf(1562KB)期刊论文作者接受稿限制开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[万冬云]的文章
[何庆]的文章
[贾全杰]的文章
百度学术
百度学术中相似的文章
[万冬云]的文章
[何庆]的文章
[贾全杰]的文章
必应学术
必应学术中相似的文章
[万冬云]的文章
[何庆]的文章
[贾全杰]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。