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Neurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxide particles in mice
Wang B(汪冰); Feng WY(丰伟悦); Zhu MT(朱墨桃); Wang Y(王云); Wang M(王萌); Ou YH(欧阳宏); Wang HJ(王华建); Li M(李明); Zhao YL(赵宇亮); Chai ZF(柴之芳); Wang, B; Feng, WY; Zhu, MT; Wang, Y; Wang, M; Gu, YQ; Ouyang, H; Wang, HJ; Li, M; Zhao, YL; Chai, ZF; Wang, HF
2009
发表期刊JOURNAL OF NANOPARTICLE RESEARCH
卷号11期号:1页码:#REF!
通讯作者Feng, WY (reprint author), Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China.
摘要Olfactory tract has been demonstrated to be an important portal for inhaled solid nanoparticle transportation into the central nervous system (CNS). We have previously demonstrated that intranasally instilled Fe(2)O(3) nanoparticles could transport into the CNS via olfactory pathway. In this study, we investigated the neurotoxicity and size effect of repeatedly low-dose (130 mu g) intranasal exposure of nano- and submicron-sized Fe(2)O(3) particles (21 nm and 280 nm) to mice. The biomarkers of oxidative stress, activity of nitric oxide synthases and release of monoamine neurotransmitter in the brain were studied. Our results showed that significant oxidative stress was induced by the two sizes of Fe(2)O(3) particles. The activities of GSH-Px, Cu,Zn-SOD, and cNOS significantly elevated and the total GSH and GSH/GSSG ratio significantly decreased in the olfactory bulb and hippocampus after the nano- and submicron-sized Fe(2)O(3) particle treatment (p < 0.05). The nano-sized Fe(2)O(3) generally induced greater alteration and more significant dose-effect response than the submicron-sized particle did. Some slight perturbation of monoamine neurotransmitters were found in the hippocampus after exposure to the two sizes of Fe(2)O(3) particle. The TEM image showed that some ultrastructural alterations in nerve cells, including neurodendron degeneration, membranous structure disruption and lysosome increase in the olfactory bulb, slight dilation in the rough endoplasmic reticulum and lysosome increase in the hippocampus were induced by the nano-sized Fe(2)O(3) treatment. In contrast, in the submicron-sized Fe(2)O(3) treated mice, slightly swollen mitochondria and some vacuoles were observed in the olfactory bulb and hippocampus, respectively. These results indicate that intranasal exposure of Fe(2)O(3) nanoparticles could induce more severe oxidative stress and nerve cell damage in the brain than the larger particle did. This is the first study to compare the neurotoxicity of nano- and submicron-sized Fe(2)O(3) particles in the central nervous system after long-term and low-dose intranasal exposure.
文章类型Article
关键词Neurotoxicity Ferric oxide nanoparticle Submicron-sized Central nervous system Mice Nanotechnology Occupational health EHS
学科领域Chemistry; Science & Technology - Other Topics; Materials Science
DOI10.1007/s11051-008-9452-6
收录类别SCI
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000262125200005
引用统计
被引频次:68[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225691
专题院士
加速器中心
粒子天体物理中心
多学科研究中心
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Wang B,Feng WY,Zhu MT,et al. Neurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxide particles in mice[J]. JOURNAL OF NANOPARTICLE RESEARCH,2009,11(1):#REF!.
APA 汪冰.,丰伟悦.,朱墨桃.,王云.,王萌.,...&Wang, HF.(2009).Neurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxide particles in mice.JOURNAL OF NANOPARTICLE RESEARCH,11(1),#REF!.
MLA 汪冰,et al."Neurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxide particles in mice".JOURNAL OF NANOPARTICLE RESEARCH 11.1(2009):#REF!.
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