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Brain volume alteration and the correlations with the clinical characteristics in drug-naive first-episode MDD patients: A voxel-based morphometry study
Cheng, YQ; Xu, JA; Chai P(柴培); Chai, P; Li, HJ; Luo, CR; Yang, T; Li, L; Shan, BC; Xu, XF; Xu, L; Li L(李琳); Dan BC(单保慈)
2010
发表期刊NEUROSCIENCE LETTERS
卷号480期号:1页码:#REF!
通讯作者Xu, XF (reprint author), 295 Xi Chang Rd, Kunming 650032, Peoples R China.
文章类型Article
摘要Structural brain abnormalities have been widely reported in major depressive disorder (MDD). However, many previous results cannot exclude the interferences of medication or multiple recurrent episodes. In this study, we examined structural brain abnormalities by comparing 68 drug-naive first-episode adult-onset MDD and 68 healthy controls (HCs). Structural magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) methods were used. The mean values of grey matter volume/white matter volume (GMV/WMV) were calculated, then the differences between MDD and HCs were analyzed, and the associations of the differences with clinical characteristics of depression were discussed. The whole brain GMV/WMV did not differ between MDD patients and HCs; however, the regional GMV of the right pre-supplementary motor area (pre-SMA) was smaller in MDD patients. The GMV of both hippocampi was positively correlated with symptom severity and lower in patients with long durations. These results indicate the GMV reduction of the pre-SMA at an early stage of depression, whereas the GMV of the hippocampus is associated with depressive characteristics. Moreover, the whole brain GMV/WMV was negatively related to the duration of depression, supporting that volume loss could become progressive during the development of disease. These results may suggest the importance of identifying and intervening depression at an early stage, especially the first year after onset, to prevent volume loss in the brain. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
关键词Major depressive disorder First episode Neuroimaging Drug-naive Adult-onset
学科领域Neurosciences & Neurology
DOI10.1016/j.neulet.2010.05.075
收录类别SCI
WOS类目Neurosciences
WOS记录号WOS:000280471400008
引用统计
被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225617
专题多学科研究中心
中国科学院高能物理研究所_中国散裂中子源
核技术应用研究中心
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GB/T 7714
Cheng, YQ,Xu, JA,Chai P,et al. Brain volume alteration and the correlations with the clinical characteristics in drug-naive first-episode MDD patients: A voxel-based morphometry study[J]. NEUROSCIENCE LETTERS,2010,480(1):#REF!.
APA Cheng, YQ.,Xu, JA.,柴培.,Chai, P.,Li, HJ.,...&单保慈.(2010).Brain volume alteration and the correlations with the clinical characteristics in drug-naive first-episode MDD patients: A voxel-based morphometry study.NEUROSCIENCE LETTERS,480(1),#REF!.
MLA Cheng, YQ,et al."Brain volume alteration and the correlations with the clinical characteristics in drug-naive first-episode MDD patients: A voxel-based morphometry study".NEUROSCIENCE LETTERS 480.1(2010):#REF!.
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