Rapid translocation and pharmacokinetics of hydroxylated single-walled carbon nanotubes in mice

doi:10.1080/17435390701851747

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	Rapid translocation and pharmacokinetics of hydroxylated single-walled carbon nanotubes in mice
	Wang, J; Deng, XY; Yang, ST; Wang, HF; Zhao, YL; Liu, YF; Zhao YL(赵宇亮)
	2008
发表期刊	NANOTOXICOLOGY
卷号	2 期号:1 页码:#REF!
通讯作者	Wang, HF (reprint author), Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China.
文章类型	Article
摘要	Determining the in vivo pharmacological profiles of carbon nanotubes (CNTs) is essential for the promising biomedical applications of CNTs, such as drug delivery. Using iodine-131 tracing we studied the fundamental behavior of hydroxylated single-walled CNTs (SWNTols) shortly after they were introduced into the animal body (from 2 min to 1 h) by providing the biodistribution data and pharmacokinetic parameters. The distribution was slightly influenced by injection modes, but in any mode radioactivity was found all over the body within 2 min except brain. Liver, kidneys, stomach and lungs are the target organs with high uptake of SWNTols. The SWNTols content in several tissues, such as heart, lungs, and muscle is positively correlated with its content in the blood, showing clearly that the blood stream brings SWNTols to the whole body. This work presents the initial in vivo behavior of the water-soluble functionalized SWNTs, providing also the basic data to show opportunities and limitations for realization of the CNT-based drug vehicle.
关键词	Hydroxylated single-walled carbon nanotubes (SWNTols) I-131 biodistribution pharmacokinetics mice
学科领域	Science & Technology - Other Topics; Toxicology
DOI	10.1080/17435390701851747
收录类别	SCI
WOS类目	Nanoscience & Nanotechnology ; Toxicology
WOS记录号	WOS:000260296900003
引用统计	被引频次：47[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ihep.ac.cn/handle/311005/225597
专题	多学科研究中心
推荐引用方式 GB/T 7714	Wang, J,Deng, XY,Yang, ST,et al. Rapid translocation and pharmacokinetics of hydroxylated single-walled carbon nanotubes in mice[J]. NANOTOXICOLOGY,2008,2(1):#REF!.
APA	Wang, J.,Deng, XY.,Yang, ST.,Wang, HF.,Zhao, YL.,...&赵宇亮.(2008).Rapid translocation and pharmacokinetics of hydroxylated single-walled carbon nanotubes in mice.NANOTOXICOLOGY,2(1),#REF!.
MLA	Wang, J,et al."Rapid translocation and pharmacokinetics of hydroxylated single-walled carbon nanotubes in mice".NANOTOXICOLOGY 2.1(2008):#REF!.

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