| Rapid translocation and pharmacokinetics of hydroxylated single-walled carbon nanotubes in mice | |
Wang, J; Deng, XY; Yang, ST; Wang, HF; Zhao, YL; Liu, YF; Zhao YL(赵宇亮)
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| 2008 | |
| 发表期刊 | NANOTOXICOLOGY
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| 卷号 | 2期号:1页码:#REF! |
| 通讯作者 | Wang, HF (reprint author), Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China. |
| 摘要 | Determining the in vivo pharmacological profiles of carbon nanotubes (CNTs) is essential for the promising biomedical applications of CNTs, such as drug delivery. Using iodine-131 tracing we studied the fundamental behavior of hydroxylated single-walled CNTs (SWNTols) shortly after they were introduced into the animal body (from 2 min to 1 h) by providing the biodistribution data and pharmacokinetic parameters. The distribution was slightly influenced by injection modes, but in any mode radioactivity was found all over the body within 2 min except brain. Liver, kidneys, stomach and lungs are the target organs with high uptake of SWNTols. The SWNTols content in several tissues, such as heart, lungs, and muscle is positively correlated with its content in the blood, showing clearly that the blood stream brings SWNTols to the whole body. This work presents the initial in vivo behavior of the water-soluble functionalized SWNTs, providing also the basic data to show opportunities and limitations for realization of the CNT-based drug vehicle. |
| 文章类型 | Article |
| 关键词 | Hydroxylated single-walled carbon nanotubes (SWNTols) I-131 biodistribution pharmacokinetics mice |
| 学科领域 | Science & Technology - Other Topics; Toxicology |
| DOI | 10.1080/17435390701851747 |
| 收录类别 | SCI |
| WOS类目 | Nanoscience & Nanotechnology ; Toxicology |
| WOS记录号 | WOS:000260296900003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ihep.ac.cn/handle/311005/225597 |
| 专题 | 多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Wang, J,Deng, XY,Yang, ST,et al. Rapid translocation and pharmacokinetics of hydroxylated single-walled carbon nanotubes in mice[J]. NANOTOXICOLOGY,2008,2(1):#REF!. |
| APA | Wang, J.,Deng, XY.,Yang, ST.,Wang, HF.,Zhao, YL.,...&赵宇亮.(2008).Rapid translocation and pharmacokinetics of hydroxylated single-walled carbon nanotubes in mice.NANOTOXICOLOGY,2(1),#REF!. |
| MLA | Wang, J,et al."Rapid translocation and pharmacokinetics of hydroxylated single-walled carbon nanotubes in mice".NANOTOXICOLOGY 2.1(2008):#REF!. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 365.pdf（1469KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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