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Distribution of some rare earth elements and their binding species with proteins in human liver studied by instrumental neutron activation analysis combined with biochemical techniques
Chen CY(陈春英); Zhang PQ(章佩群); Chai ZF(柴之芳); Chen, CY; Zhang, PQ; Chai, ZF
刊名ANALYTICA CHIMICA ACTA
2001
卷号439期号:1页码:#REF!
关键词rare earth elements subcellular distribution human liver REE-binding protein neutron activation analysis
学科分类Chemistry
DOI10.1016/S0003-2670(01)01024-8
通讯作者Chen, CY (reprint author), Chinese Acad Sci, Lab Nucl Analyt Techniques, Inst High Energy Phys, POB 2732, Beijing 100080, Peoples R China.
文章类型Article
英文摘要Distribution patterns of three rare earth elements and their binding species with proteins in the human liver samples were studied by instrumental neutron activation analysis combined with biochemical techniques. It was indicated that La, Ce and Sm were highly concentrated in microsomes, although the total content of this fraction was the least among all of the liver organelles, which was similar with the behavior of Ca and Fe. More than 85% of La, Ce and Sm was present in the cytosolic protein fractions separated by ammonium sulfate and ethanol. It indicated that these elements were mainly incorporated into protein. It was also revealed by means of size-exclusion chromatography that at least three La-binding proteins (M-x: 335 +/- 50, 94.5 +/- 15.4, 13.6 +/- 3.8 kD), three Ce-binding proteins (M-w: 335 +/- 50, 85.1 +/- 12.0, 22.8 +/- 6.3 kD) and about four Sm-binding proteins (M-w: 335 +/- 70, 82.1 +/- 5.4, 32.3 +/- 5.8 and 13.6 +/- 4.5kD) were present in the supernatant fraction of human liver. Most of La, Ce and Sm were found in the high-molecular weight protein region. (C) 2001 Elsevier Science B.V. All rights reserved.
类目[WOS]Chemistry, Analytical
收录类别SCI
WOS记录号WOS:000169905600003
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被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225534
专题院士_期刊论文
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Chen CY,Zhang PQ,Chai ZF,et al. Distribution of some rare earth elements and their binding species with proteins in human liver studied by instrumental neutron activation analysis combined with biochemical techniques[J]. ANALYTICA CHIMICA ACTA,2001,439(1):#REF!.
APA 陈春英,章佩群,柴之芳,Chen, CY,Zhang, PQ,&Chai, ZF.(2001).Distribution of some rare earth elements and their binding species with proteins in human liver studied by instrumental neutron activation analysis combined with biochemical techniques.ANALYTICA CHIMICA ACTA,439(1),#REF!.
MLA 陈春英,et al."Distribution of some rare earth elements and their binding species with proteins in human liver studied by instrumental neutron activation analysis combined with biochemical techniques".ANALYTICA CHIMICA ACTA 439.1(2001):#REF!.
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