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Visual attention deficits in Alzheimer's disease: an fMRI study
Hao, J; Li, KC; Li, K; Zhang, DX; Wang, W; Yang, YH; Yan, B; Shan, BC; Zhou, XL; Li K(李可); Yan B(闫镔); Dan BC(单保慈)
2005
发表期刊NEUROSCIENCE LETTERS
卷号385期号:1页码:#REF!
通讯作者Li, KC (reprint author), Capital Univ Med Sci, Xuanwu Hosp, Dept Radiol, 45 Changchun St, Beijing 100053, Peoples R China.
摘要Cognitive and neuroscience studies indicate that attentional operations are impaired in Alzheimer's disease (AD). Our goal was to define the anatomical areas of activation associated with visual attention processing and to define deficits or changes that may occur in AD patients compared with control group. Thirteen AD patients and 13 age- and education-matched normal controls were tested in two visual search tasks (one was a conjunction task, where feature binding is required. The other was a subset task, where group stimuli is needed without feature binding) using fMRI techniques. After stereotactical normalization, voxel-by-voxel t statistics was used to compare activated brain areas between patients and control subjects. Our findings suggest that both search tasks are controlled by partially overlapping cerebral networks, including parietal, frontal and occipital-temporal cortical regions and primary visual cortex. The AD patient group showed less activation in both parietal lobes and the left frontal regions, while increased activation was found in the right frontal lobes and the right occipito-temporal cortical regions with the conjunction task. In the subset task, decreased activation in AD patients was seen in the left parietal lobe and bilateral frontal lobes, while increased activation was seen in both medial temporal lobes. In addition, for the comparison between tasks, The difference is very small for AD patients. Control group showed a higher amplitude in the fight prefrontal region, temporal cortical regions and parietal lobe. These results indicate that attention deficits in AD patients may be attributed to both binding problem and grouping inefficiency. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
文章类型Article
关键词functional MRI visual search attention Alzheimer's disease
学科领域Neurosciences & Neurology
DOI10.1016/j.neulet.2005.05.028
收录类别SCI
WOS类目Neurosciences
WOS记录号WOS:000230745800004
引用统计
被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225528
专题多学科研究中心
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GB/T 7714
Hao, J,Li, KC,Li, K,et al. Visual attention deficits in Alzheimer's disease: an fMRI study[J]. NEUROSCIENCE LETTERS,2005,385(1):#REF!.
APA Hao, J.,Li, KC.,Li, K.,Zhang, DX.,Wang, W.,...&单保慈.(2005).Visual attention deficits in Alzheimer's disease: an fMRI study.NEUROSCIENCE LETTERS,385(1),#REF!.
MLA Hao, J,et al."Visual attention deficits in Alzheimer's disease: an fMRI study".NEUROSCIENCE LETTERS 385.1(2005):#REF!.
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