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Study on the metabolism of physiological amounts of Cr(III) intragastrical administration in normal rats using activable enriched stable isotope Cr-50 compound as a tracer
Feng WY(丰伟悦); Ding WJ(丁万见); Qian QF(钱琴芳); Chai ZF(柴之芳); Feng, WY; Ding, WJ; Qian, QF; Chai, ZF
1998
发表期刊JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
卷号237期号:1-2页码:#REF!
通讯作者Feng, WY (reprint author), Chinese Acad Sci, Inst High Energy Phys, POB 2732, Beijing 100080, Peoples R China.
文章类型Article
摘要In order to study the metabolism of physiological amounts of Cr-51 (10 mu g/100 g of body wt.) intragastrically administered in rats, the activable enriched stable isotope Cr-50 compound Cr2O3 was used as a tracer. The absorption and distribution of Cr-51(III) in rats with time were studied. Significant Cr-51 contents were found in all the organs and tissues of interest. The kidney, liver and bone contain higher amounts of Cr-51 than others. The fact that specific activities of Cr-51 are notably high in kidney, bone, spleen and pancreas and decrease gradually with time suggests that there are tighter binding of chromium in these organs. The excretion of Cr-51 at various time intervals was also studied. Almost totally intragastrically administered dose was excreted in the feces. The increased urinary excretion of Cr-51 with time indicates that the urine-chromium is the metabolic derivative of organism. In view of the tissues distribution and excretion, it can be concluded that no more than 1% of the dose was absorbed from the gastrointestinal tract.
学科领域Chemistry; Nuclear Science & Technology
DOI10.1007/BF02386655
收录类别SCI
WOS类目Chemistry, Analytical ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology
WOS记录号WOS:000077298200004
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225510
专题院士
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Feng WY,Ding WJ,Qian QF,et al. Study on the metabolism of physiological amounts of Cr(III) intragastrical administration in normal rats using activable enriched stable isotope Cr-50 compound as a tracer[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,1998,237(1-2):#REF!.
APA 丰伟悦.,丁万见.,钱琴芳.,柴之芳.,Feng, WY.,...&Chai, ZF.(1998).Study on the metabolism of physiological amounts of Cr(III) intragastrical administration in normal rats using activable enriched stable isotope Cr-50 compound as a tracer.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,237(1-2),#REF!.
MLA 丰伟悦,et al."Study on the metabolism of physiological amounts of Cr(III) intragastrical administration in normal rats using activable enriched stable isotope Cr-50 compound as a tracer".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 237.1-2(1998):#REF!.
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