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Tyrosine phosphorylation/dephosphorylation regulates peroxynitrite-mediated peptide nitration
Shi WQ(石伟群); Xu DD(徐殿斗); Shi, WQ; Cai, H; Xu, DD; Su, XY; Lei, P; Zhao, YF; Li, YM
2007
发表期刊REGULATORY PEPTIDES
卷号144期号:1-3页码:1-5
通讯作者Li, YM (reprint author), Tsing Hua Univ, Dept Chem, Key Lab Bioorgan Phosphorous Chem, Beijing 100084, Peoples R China.
文章类型Article
摘要Proteins are targets of reactive nitrogen species such as peroxynitrite and nitrogen dioxide. Among the various amino acids in proteins, tyrosine and tryptophan residues are especially susceptible to attack by reactive nitrogen species. On the other hand, protein tyrosine phosphorylation has gained much attention in respect to cellular regulatory events and signal transduction. Peroxynitrite-mediated nitration of peptide YPPPPPW and phosphopeptide pYPPPPPW were studied at pH 7.4. The predominant nitrated products were separated and identified by reverse phase high performance liquid chromatography coupled with electrospray ionization mass spectrometry (LC-MS). The nitration sites were established by tandem electrospray ionization-mass spectrometry (LC-MS/MS). A regulatory effect of tyrosine phosphorylation/dephosphorylation on peptide nitration was observed. YPPPPPW was predominantly nitrated at tyrosine residue while pYPPPPPW was nitrated at tryptophan one. Our results can help in understanding the biochemical significance of the relationship of tyrosine phosphorylation and nitration in proteins. (c) 2007 Elsevier B.V All rights reserved.
关键词tyrosine tryptophan nitration phosphorylation peroxynitrite
学科领域Endocrinology & Metabolism; Physiology
DOI10.1016/j.regpep.2007.06.011
收录类别SCI
WOS类目Endocrinology & Metabolism ; Physiology
WOS记录号WOS:000251601800001
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225436
专题多学科研究中心
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GB/T 7714
Shi WQ,Xu DD,Shi, WQ,et al. Tyrosine phosphorylation/dephosphorylation regulates peroxynitrite-mediated peptide nitration[J]. REGULATORY PEPTIDES,2007,144(1-3):1-5.
APA 石伟群.,徐殿斗.,Shi, WQ.,Cai, H.,Xu, DD.,...&Li, YM.(2007).Tyrosine phosphorylation/dephosphorylation regulates peroxynitrite-mediated peptide nitration.REGULATORY PEPTIDES,144(1-3),1-5.
MLA 石伟群,et al."Tyrosine phosphorylation/dephosphorylation regulates peroxynitrite-mediated peptide nitration".REGULATORY PEPTIDES 144.1-3(2007):1-5.
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