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Integrated analytical techniques with high sensitivity for studying brain translocation and potential impairment induced by intranasally instilled copper nanoparticles
Bai R(白茹); Zhang LL(张丽丽); Liu Y(刘颖); Bai, R; Zhang, LL; Liu, Y; Li, B; Wang, LM; Wang, P; Autrup, H; Beer, C; Chen, CY; Li B(李柏); Wang LM(王黎明); Wang P(王鹏); Chen CY(陈春英)
2014
发表期刊TOXICOLOGY LETTERS
卷号226期号:1页码:70-80
摘要Health impacts of inhalation exposure to engineered nanomaterials have attracted increasing attention. In this paper, integrated analytical techniques with high sensitivity were used to study the brain translocation and potential impairment induced by intranasally instilled copper nanoparticles (CuNPs). Mice were exposed to CuNPs in three doses (1, 10, 40 mg/kg bw). The body weight of mice decreased significantly in the 10 and 40 mg/kg group (p < 0.05) but recovered slightly within exposure duration. Inductively coupled plasma mass spectrometry (ICP-MS) analysis showed that CuNPs could enter the brain. Altered distribution of some important metal elements was observed by synchrotron radiation X-ray fluorescence (SRXRF). H&E staining and immunohistochemical analysis showed that CuNPs produced damages to nerve cells and astrocyte might be the one of the potential targets of CuNPs. The changes of neurotransmitter levels in different brain regions demonstrate that the dysfunction occurred in exposed groups. These data indicated that CuNPs could enter the brain after nasal inhalation and induced damages to the central nervous system (CNS). Integration of effective analytical techniques for systematic investigations is a promising direction to better understand the biological activities of nanomaterials. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
关键词Copper nanoparticles Brain translocation ICP-MS SRXRF Histopathological examination
学科领域Toxicology
DOI10.1016/j.toxlet.2014.01.041
收录类别SCI
WOS记录号WOS:000332409000010
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225384
专题多学科研究中心
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GB/T 7714
Bai R,Zhang LL,Liu Y,et al. Integrated analytical techniques with high sensitivity for studying brain translocation and potential impairment induced by intranasally instilled copper nanoparticles[J]. TOXICOLOGY LETTERS,2014,226(1):70-80.
APA 白茹.,张丽丽.,刘颖.,Bai, R.,Zhang, LL.,...&陈春英.(2014).Integrated analytical techniques with high sensitivity for studying brain translocation and potential impairment induced by intranasally instilled copper nanoparticles.TOXICOLOGY LETTERS,226(1),70-80.
MLA 白茹,et al."Integrated analytical techniques with high sensitivity for studying brain translocation and potential impairment induced by intranasally instilled copper nanoparticles".TOXICOLOGY LETTERS 226.1(2014):70-80.
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