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Multifunctional Rb-x WO3 Nanorods for Simultaneous Combined Chemo-photothermal Therapy and Photoacoustic/CT Imaging
Tian G(田甘); Zhang X(张潇); Zheng XP(郑晓鹏); Tian, G; Zhang, X; Zheng, XP; Yin, WY; Ruan, LF; Liu, XD; Zhou, LJ; Yan, L; Li, SJ; Gu, ZJ; Zhao, YL; Yin WY(尹文艳); Ruan LF(阮龙飞); Liu XD(刘晓东); Zhou LJ(周亮君); Yan L(晏亮); Gu ZJ(谷战军); Zhao YL(赵宇亮)
2014
Source PublicationSMALL
ISSN1613-6810
EISSN1613-6829
Volume10Issue:20Pages:4160-4170
AbstractLight-triggered drug delivery based on near-infrared (NIR)-mediated photothermal nanocarriers has received tremendous attention for the construction of cooperative therapeutic systems in nanomedicine. Herein, a new paradigm of light-responsive drug carrier that doubles as a photothermal agent is reported based on the NIR light-absorber, Rb (x) WO3 (rubidium tungsten bronze, Rb-TB) nanorods. With doxorubicin (DOX) payload, the DOX-loaded Rb-TB composite (Rb-TB-DOX) simultaneously provides a burst-like drug release and intense heating effect upon 808-nm NIR light exposure. MTT assays show the photothermally enhanced antitumor activity of Rb-TB-DOX to the MCF-7 cancer cells. Most remarkably, Rb-TB-DOX combined with NIR irradiation also shows dramatically enhanced chemotherapeutic effect to DOX-resistant MCF-7 cells compared with free DOX, demonstrating the enhanced efficacy of combinational chemo-photothermal therapy for potentially overcoming drug resistance in cancer chemotherapy. Furthermore, in vivo study of combined chemo-photothermal therapy is also conducted and realized on pancreatic (Pance-1) tumor-bearing nude mice. Apart from its promise for cancer therapy, the as-prepared Rb-TB can also be employed as a new dual-modal contrast agent for photoacoustic tomography and (PAT) X-ray computed tomography (CT) imaging because of its high NIR optical absorption capability and strong X-ray attenuation ability, respectively. The results presented in the current study suggest promise of the multifunctional Rb (x) WO3 nanorods for applications in cancer theranostics.
KeywordRbxWO3 NIR light-responsive drug delivery synergy dual-modal bioimaging theranostics
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1002/smll.201401237
Indexed BySCI
Language英语
WOS IDWOS:000344452500017
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/225373
Collection多学科研究中心
Recommended Citation
GB/T 7714
Tian G,Zhang X,Zheng XP,et al. Multifunctional Rb-x WO3 Nanorods for Simultaneous Combined Chemo-photothermal Therapy and Photoacoustic/CT Imaging[J]. SMALL,2014,10(20):4160-4170.
APA 田甘.,张潇.,郑晓鹏.,Tian, G.,Zhang, X.,...&赵宇亮.(2014).Multifunctional Rb-x WO3 Nanorods for Simultaneous Combined Chemo-photothermal Therapy and Photoacoustic/CT Imaging.SMALL,10(20),4160-4170.
MLA 田甘,et al."Multifunctional Rb-x WO3 Nanorods for Simultaneous Combined Chemo-photothermal Therapy and Photoacoustic/CT Imaging".SMALL 10.20(2014):4160-4170.
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