Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma
Li, JQ; Li, L; 陈汉清;Chen, HQ; Chang, Q; Liu, XD; Wu, Y; Wei, CX; Li, R; Kwan, JKC; Yeung, KL; Xi, ZG; Lu, ZS; Yang, X
刊名SCIENTIFIC REPORTS
2014
卷号4页码:4275
学科分类Science & Technology - Other Topics
DOI10.1038/srep04275
英文摘要The aggravating effects of zero-dimensional, particle-shaped nanomaterials on allergic asthma have been previously investigated, but similar possible effects of one-dimensional shaped nanomaterials have not been reported. More importantly, there are no available means to counteract the adverse nanomaterial effects to allow for their safe use. In this study, an ovalbumin (OVA)-sensitized rat asthma model was established to investigate whether single walled carbon nanotubes (SWCNTs) aggravate allergic asthma. The results showed that SWCNTs in rats exacerbated OVA-induced allergic asthma and that this exacerbation was counteracted by concurrent administration vitamin E. A mechanism involving the elimination of reactive oxygen species, downregulation of Th2 responses, reduced Ig production, and the relief of allergic asthma symptoms was proposed to explain the antagonistic effects of vitamin E. This work could provide a universal strategy to effectively protect people with allergic asthma from SWCNTs or similar nanomaterial-induced aggravating effects.
收录类别SCI
WOS记录号WOS:000332203300003
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225365
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
推荐引用方式
GB/T 7714
Li, JQ,Li, L,陈汉清;Chen, HQ,et al. Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma[J]. SCIENTIFIC REPORTS,2014,4:4275.
APA Li, JQ.,Li, L.,陈汉清;Chen, HQ.,Chang, Q.,Liu, XD.,...&Yang, X.(2014).Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma.SCIENTIFIC REPORTS,4,4275.
MLA Li, JQ,et al."Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma".SCIENTIFIC REPORTS 4(2014):4275.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
11529.pdf(2230KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, JQ]的文章
[Li, L]的文章
[陈汉清;Chen, HQ]的文章
百度学术
百度学术中相似的文章
[Li, JQ]的文章
[Li, L]的文章
[陈汉清;Chen, HQ]的文章
必应学术
必应学术中相似的文章
[Li, JQ]的文章
[Li, L]的文章
[陈汉清;Chen, HQ]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 11529.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。