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A Statistical Parametric Mapping Toolbox Used for Voxel-Wise Analysis of FDG-PET Images of Rat Brain
Nie BB(聂彬彬); Liu H(刘华); Nie, BB; Liu, H; Chen, KW; Jiang, XF; Shan, BC;; Dan BC(单保慈)
2014
发表期刊PLOS ONE
卷号9期号:9页码:e108295
摘要Purpose: PET (positron emission tomography) imaging researches of functional metabolism using fluorodeoxyglucose (F-18-FDG) of animal brain are important in neuroscience studies. FDG-PET imaging studies are often performed on groups of rats, so it is desirable to establish an objective voxel-based statistical methodology for group data analysis. Material and Methods: This study establishes a statistical parametric mapping (SPM) toolbox (plug-ins) named spmratIHEP for voxel-wise analysis of FDG-PET images of rat brain, in which an FDG-PET template and an intracranial mask image of rat brain in Paxinos & Watson space were constructed, and the default settings were modified according to features of rat brain. Compared to previous studies, our constructed rat brain template comprises not only the cerebrum and cerebellum, but also the whole olfactory bulb which made the later cognitive studies much more exhaustive. And with an intracranial mask image in the template space, the brain tissues of individuals could be extracted automatically. Moreover, an atlas space is used for anatomically labeling the functional findings in the Paxinos & Watson space. In order to standardize the template image with the atlas accurately, a synthetic FDG-PET image with six main anatomy structures is constructed from the atlas, which performs as a target image in the co-registration. Results: The spatial normalization procedure is evaluated, by which the individual rat brain images could be standardized into the Paxinos & Watson space successfully and the intracranial tissues could also be extracted accurately. The practical usability of this toolbox is evaluated using FDG-PET functional images from rats with left side middle cerebral artery occlusion (MCAO) in comparison to normal control rats. And the two-sample t-test statistical result is almost related to the left side MCA. Conclusion: We established a toolbox of SPM8 named spmratIHEP for voxel-wise analysis of FDG-PET images of rat brain.
学科领域Science & Technology - Other Topics
DOI10.1371/journal.pone.0108295
收录类别SCI
WOS记录号WOS:000342685600061
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225311
专题核技术应用研究中心
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GB/T 7714
Nie BB,Liu H,Nie, BB,et al. A Statistical Parametric Mapping Toolbox Used for Voxel-Wise Analysis of FDG-PET Images of Rat Brain[J]. PLOS ONE,2014,9(9):e108295.
APA 聂彬彬.,刘华.,Nie, BB.,Liu, H.,Chen, KW.,...&单保慈.(2014).A Statistical Parametric Mapping Toolbox Used for Voxel-Wise Analysis of FDG-PET Images of Rat Brain.PLOS ONE,9(9),e108295.
MLA 聂彬彬,et al."A Statistical Parametric Mapping Toolbox Used for Voxel-Wise Analysis of FDG-PET Images of Rat Brain".PLOS ONE 9.9(2014):e108295.
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