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Spatial Patterns of Whole Brain Grey and White Matter Injury in Patients with Occult Spastic Diplegic Cerebral Palsy
Mu, XT; Nie BB(聂彬彬); Nie, BB; Wang, H; Duan, SF; Zhang, Z; Dai, GH; Ma, QZ; Shan, BC; Ma, L; Duan SF(段邵峰); Dan BC(单保慈)
2014
发表期刊PLOS ONE
卷号9期号:6页码:e100451
摘要Spastic diplegic cerebral palsy(SDCP) is a common type of cerebral palsy (CP), which presents as a group of motor-impairment syndromes. Previous conventional MRI studies have reported abnormal structural changes in SDCP, such as periventricular leucomalacia. However, there are roughly 27.8% SDCP patients presenting normal appearance in conventional MRI, which were considered as occult SDCP. In this study, sixteen patients with occult SDCP and 16 age-and sex-matched healthy control subjects were collected and the data were acquired on a 3T MR system. We applied voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analysis to investigate whole brain grey and white matter injury in occult SDCP. By using VBM method, the grey matter volume reduction was revealed in the bilateral basal ganglia regions, thalamus, insula, and left cerebral peduncle, whereas the white matter atrophy was found to be located in the posterior part of corpus callosum and right posterior corona radiata in the occult SDCP patients. By using TBSS, reduced fractional anisotropy (FA) values were detected in multiple white matter regions, including bilateral white matter tracts in prefrontal lobe, temporal lobe, internal and external capsule, corpus callosum, cingulum, thalamus, brainstem and cerebellum. Additionally, several regions of white matter tracts injury were found to be significantly correlated with motor dysfunction. These results collectively revealed the spatial patterns of whole brain grey and white matter injury in occult SDCP.
学科领域Science & Technology - Other Topics
DOI10.1371/journal.pone.0100451
收录类别SCI
WOS记录号WOS:000338709500052
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225310
专题核技术应用研究中心
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Mu, XT,Nie BB,Nie, BB,et al. Spatial Patterns of Whole Brain Grey and White Matter Injury in Patients with Occult Spastic Diplegic Cerebral Palsy[J]. PLOS ONE,2014,9(6):e100451.
APA Mu, XT.,聂彬彬.,Nie, BB.,Wang, H.,Duan, SF.,...&单保慈.(2014).Spatial Patterns of Whole Brain Grey and White Matter Injury in Patients with Occult Spastic Diplegic Cerebral Palsy.PLOS ONE,9(6),e100451.
MLA Mu, XT,et al."Spatial Patterns of Whole Brain Grey and White Matter Injury in Patients with Occult Spastic Diplegic Cerebral Palsy".PLOS ONE 9.6(2014):e100451.
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