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Graphene oxide as an anaerobic membrane scaffold for the enhancement of B. adolescentis proliferation and antagonistic effects against pathogens E-coli and S-aureus
Chen HQ(陈汉清); Gao D(高迪); Wang B(汪冰); Chen, HQ; Gao, D; Wang, B; Zhao, RF; Guan, M; Zheng, LN; Zhou, XY; Chai, ZF; Feng, WY; Zheng LN(郑令娜); Zhou XY(周晓艳); Chai ZF(柴之芳); Feng WY(丰伟悦)
刊名NANOTECHNOLOGY
2014
卷号25期号:16页码:165101
关键词graphene oxide gut bacteria proliferation B. adolescentis antagonistic effect
学科分类Science & Technology - Other Topics; Materials Science; Physics
DOI10.1088/0957-4484/25/16/165101
英文摘要The impact of the gut microbiota on human health is widely perceived as the most exciting advancement in biomedicine. The gut microbiota has been known to play a crucial role in defining states of human health and diseases, and thus becomes a potential new territory for drug targeting. Herein, graphene oxide ( GO) interaction with five common human gut bacteria, B. adolescentis, L. acidophilus, E. coli, E. faecalis, and S. aureus, was studied. It was shown that, in bacterial media, GO sheets were able to form effective, anaerobic membrane scaffolds that enhanced the antagonistic activity of B. adolescentis against the pathogens E. coli and S. aureus. Data obtained using bacterial growth measurements, colony counting and 16S rRNA gene sequencing consistently indicated that GO sheets promoted proliferation of gut bacteria, particularly for B. adolescentis. Scanning electron microscopy, atomic force microscopy images, and membrane potential measurements showed that cell membranes maintained their integrity and that no observable variations in cell morphology were induced after interaction with GO sheets, indicating good biocompatibility of GO. These results suggest the possibility of using GO sheets as efficient drug carriers in therapeutic applications to treat diseases related to the gut microbiota.
收录类别SCI
WOS记录号WOS:000333814700001
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225202
专题院士_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Chen HQ,Gao D,Wang B,et al. Graphene oxide as an anaerobic membrane scaffold for the enhancement of B. adolescentis proliferation and antagonistic effects against pathogens E-coli and S-aureus[J]. NANOTECHNOLOGY,2014,25(16):165101.
APA 陈汉清.,高迪.,汪冰.,Chen, HQ.,Gao, D.,...&丰伟悦.(2014).Graphene oxide as an anaerobic membrane scaffold for the enhancement of B. adolescentis proliferation and antagonistic effects against pathogens E-coli and S-aureus.NANOTECHNOLOGY,25(16),165101.
MLA 陈汉清,et al."Graphene oxide as an anaerobic membrane scaffold for the enhancement of B. adolescentis proliferation and antagonistic effects against pathogens E-coli and S-aureus".NANOTECHNOLOGY 25.16(2014):165101.
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