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WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells
Yong Y(雍媛); Zhou LJ(周亮君); Gu ZJ(谷战军); Yong, Y; Zhou, LJ; Gu, ZJ; Yan, L; Tian, G; Zheng, XP; Liu, XD; Zhang, X; Shi, JX; Cong, WS; Yin, WY; Zhao, YL; Yan L(晏亮); Tian G(田甘); Zheng XP(郑晓鹏); Zhang X(张潇); Shi JX(施俊新); Cong WS(丛文姝); Yin WY(尹文艳); Zhao YL(赵宇亮)
2014
Source PublicationNANOSCALE
ISSN2040-3364
EISSN2040-3372
Volume6Issue:17Pages:10394-10403
AbstractWe have developed a simple and efficient strategy to fabricate WS2 nanosheets with low toxicity and good water solubility via a liquid exfoliation method by using H2SO4 intercalation and ultrasonication. The as-prepared WS2 nanosheets were employed not only as an NIR absorbing agent for photothermal therapy (PTT) but also as a photosensitizer (PS) carrier for photodynamic therapy (PDT) due to their sheet like structure that offers large surface area to load PS molecules. Moreover, singlet-oxygen generation of the PSs-WS2 complex could be finely controlled by NIR irradiation that could manipulate the PSs release behavior from WS2 nanosheets. The synergistic anti-tumor effect of WS2 nanosheets mediated PDT-PTT was also evaluated carefully and the results clearly showed that the efficacy of combined PDT-PTT treatment of cancer cells is significantly higher than those of PDT-only and PTT-only treatment, indicating enhanced efficiency of the combined therapeutic system. In addition, the WS2 could be used as a computed tomography (CT) contrast agent for bio-imaging since W atoms have strong X-ray attenuation ability, making them a multifunctional theranostic platform for simultaneous imaging-guided diagnosis and therapy.
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1039/c4nr02453b
Indexed BySCI ; ADS
Language英语
WOS IDWOS:000340520500063
ADS Bibcode2014Nanos...610394Y
ADS URLhttps://ui.adsabs.harvard.edu/abs/2014Nanos...610394Y
ADS CITATIONShttps://ui.adsabs.harvard.edu/abs/2014Nanos...610394Y/citations
Citation statistics
Cited Times:30 [ADS]
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/225199
Collection多学科研究中心
Recommended Citation
GB/T 7714
Yong Y,Zhou LJ,Gu ZJ,et al. WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells[J]. NANOSCALE,2014,6(17):10394-10403.
APA 雍媛.,周亮君.,谷战军.,Yong, Y.,Zhou, LJ.,...&赵宇亮.(2014).WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells.NANOSCALE,6(17),10394-10403.
MLA 雍媛,et al."WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells".NANOSCALE 6.17(2014):10394-10403.
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