WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells
Yong Y(雍媛); Zhou LJ(周亮君); Gu ZJ(谷战军); Yong, Y; Zhou, LJ; Gu, ZJ; Yan, L; Tian, G; Zheng, XP; Liu, XD; Zhang, X; Shi, JX; Cong, WS; Yin, WY; Zhao, YL; Yan L(晏亮); Tian G(田甘); Zheng XP(郑晓鹏); Zhang X(张潇); Shi JX(施俊新); Cong WS(丛文姝); Yin WY(尹文艳); Zhao YL(赵宇亮)
刊名NANOSCALE
2014
卷号6期号:17页码:10394-10403
学科分类Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1039/c4nr02453b
英文摘要We have developed a simple and efficient strategy to fabricate WS2 nanosheets with low toxicity and good water solubility via a liquid exfoliation method by using H2SO4 intercalation and ultrasonication. The as-prepared WS2 nanosheets were employed not only as an NIR absorbing agent for photothermal therapy (PTT) but also as a photosensitizer (PS) carrier for photodynamic therapy (PDT) due to their sheet like structure that offers large surface area to load PS molecules. Moreover, singlet-oxygen generation of the PSs-WS2 complex could be finely controlled by NIR irradiation that could manipulate the PSs release behavior from WS2 nanosheets. The synergistic anti-tumor effect of WS2 nanosheets mediated PDT-PTT was also evaluated carefully and the results clearly showed that the efficacy of combined PDT-PTT treatment of cancer cells is significantly higher than those of PDT-only and PTT-only treatment, indicating enhanced efficiency of the combined therapeutic system. In addition, the WS2 could be used as a computed tomography (CT) contrast agent for bio-imaging since W atoms have strong X-ray attenuation ability, making them a multifunctional theranostic platform for simultaneous imaging-guided diagnosis and therapy.
收录类别SCI
WOS记录号WOS:000340520500063
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被引频次:87[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225199
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Yong Y,Zhou LJ,Gu ZJ,et al. WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells[J]. NANOSCALE,2014,6(17):10394-10403.
APA 雍媛.,周亮君.,谷战军.,Yong, Y.,Zhou, LJ.,...&赵宇亮.(2014).WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells.NANOSCALE,6(17),10394-10403.
MLA 雍媛,et al."WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells".NANOSCALE 6.17(2014):10394-10403.
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