IHEP OpenIR  > 院士
Nanometallomics: an emerging field studying the biological effects of metal-related nanomaterials
Li YF(李玉锋); Gao YX(高愈希); Chai ZF(柴之芳); 陈春英;Li, YF; Gao, YX; Chai, ZF; Chen, CY
2014
发表期刊METALLOMICS
卷号6期号:2页码:220-232
摘要Metallomics, focusing on the global and systematic understanding of the metal uptake, trafficking, role and excretion in biological systems, has attracted more and more attention. Metal-related nanomaterials, including metallic and metal-containing nanomaterials, have unique properties compared to their micro-scaled counterparts and therefore require special attention. The small size effect, surface effect, and quantum size effect directly influence the physicochemical properties of nanostructured materials and their fate and behavior in biota. However, to our knowledge, the metallomics itself did not touch this special category of materials yet. Therefore, the term "nanometallomics'' is proposed and the systematic study on the absorption, distribution, metabolism, excretion (ADME) behavior of metal-related nanomaterials in biological systems and their interactions with genes, proteins and other biomolecules will be reviewed. The ADME behavior of metal-related nanomaterials in the biological systems is influenced by their physicochemical properties, the exposure route, and the microenvironment of the deposition site. Nanomaterials may not only interact directly or indirectly with genes, proteins and other molecules to cause DNA damage, genotoxicity, immunotoxicity, and cytotoxicity, but also stimulate the immune responses, circumvent tumor resistance and inhibit tumor metastasis. Nanometallomics needs to be integrated with other omics sciences, such as genomics, proteomics and metabolomics, to explore the biomedical data and obtain the overall knowledge of underlying mechanisms, and therefore to improve the application performance and to reduce the potential risk of metal-related nanomaterials.
学科领域Biochemistry & Molecular Biology
DOI10.1039/c3mt00316g
收录类别SCI
WOS记录号WOS:000330796100005
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225180
专题院士
多学科研究中心
推荐引用方式
GB/T 7714
Li YF,Gao YX,Chai ZF,et al. Nanometallomics: an emerging field studying the biological effects of metal-related nanomaterials[J]. METALLOMICS,2014,6(2):220-232.
APA 李玉锋.,高愈希.,柴之芳.,陈春英;Li, YF.,Gao, YX.,...&Chen, CY.(2014).Nanometallomics: an emerging field studying the biological effects of metal-related nanomaterials.METALLOMICS,6(2),220-232.
MLA 李玉锋,et al."Nanometallomics: an emerging field studying the biological effects of metal-related nanomaterials".METALLOMICS 6.2(2014):220-232.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
11193.pdf(4013KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[李玉锋]的文章
[高愈希]的文章
[柴之芳]的文章
百度学术
百度学术中相似的文章
[李玉锋]的文章
[高愈希]的文章
[柴之芳]的文章
必应学术
必应学术中相似的文章
[李玉锋]的文章
[高愈希]的文章
[柴之芳]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 11193.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。