| Three-dimensional study of poly(lactic co-glycolic acid) micro-porous microspheres using hard X-ray nano-tomography |
| Wang, DJ; Li, N; Wang, ZL; Gao, K; Zhang, YM; Luo, YY; Wang, SX; Bao, Y; Shao, QG; Wu, ZY;吴自玉
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| 2014
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| 发表期刊 | JOURNAL OF SYNCHROTRON RADIATION
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| 卷号 | 21期号:5页码:1175-1179 |
| 摘要 | Poly(lactic co-glycolic acid) (PLGA) is widely used in diverse fields, especially in delivering biologically active proteins and drugs. For these applications, the knowledge of morphology and microstructure of PLGA micro-porous microspheres is of great importance since they strongly influence the drug delivering efficiency. In this study, micro-porous PLGA microspheres loaded by bovine serum albumin are investigated by using a full-field Zernike phase contrast transmission hard X-ray microscope. From three-dimensional reconstructions and segmentations, fundamental microstructural parameters such as size, shape, distribution and volume ratio among pores and proteins inside PLGA microspheres were obtained. These parameters are useful to understand the relationship between the internal microstructure and drug encapsulation, as well as the drug release efficiency of PLGA microspheres. The presented results demonstrate the capability of hard X-ray nano-tomography to characterize porous microspheres loaded with proteins and drugs, and also open a way to analyse, optimize and design new PLGA microspheres for specific applications. |
| 关键词 | hard X-ray imaging
nano-tomography
PLGA microspheres
salt concentration
drug delivery
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| 学科领域 | Instruments & Instrumentation; Optics; Physics
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| DOI | 10.1107/S1600577514014611
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| 收录类别 | SCI
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| WOS记录号 | WOS:000341687000035
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.ihep.ac.cn/handle/311005/225171
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| 专题 | 多学科研究中心
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推荐引用方式
GB/T 7714 |
Wang, DJ,Li, N,Wang, ZL,et al. Three-dimensional study of poly(lactic co-glycolic acid) micro-porous microspheres using hard X-ray nano-tomography[J]. JOURNAL OF SYNCHROTRON RADIATION,2014,21(5):1175-1179.
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| APA |
Wang, DJ.,Li, N.,Wang, ZL.,Gao, K.,Zhang, YM.,...&Wu, ZY；吴自玉.(2014).Three-dimensional study of poly(lactic co-glycolic acid) micro-porous microspheres using hard X-ray nano-tomography.JOURNAL OF SYNCHROTRON RADIATION,21(5),1175-1179.
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| MLA |
Wang, DJ,et al."Three-dimensional study of poly(lactic co-glycolic acid) micro-porous microspheres using hard X-ray nano-tomography".JOURNAL OF SYNCHROTRON RADIATION 21.5(2014):1175-1179.
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