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Three-dimensional study of poly(lactic co-glycolic acid) micro-porous microspheres using hard X-ray nano-tomography
Wang, DJ; Li, N; Wang, ZL; Gao, K; Zhang, YM; Luo, YY; Wang, SX; Bao, Y; Shao, QG; Wu, ZY;吴自玉
2014
发表期刊JOURNAL OF SYNCHROTRON RADIATION
卷号21期号:5页码:1175-1179
摘要Poly(lactic co-glycolic acid) (PLGA) is widely used in diverse fields, especially in delivering biologically active proteins and drugs. For these applications, the knowledge of morphology and microstructure of PLGA micro-porous microspheres is of great importance since they strongly influence the drug delivering efficiency. In this study, micro-porous PLGA microspheres loaded by bovine serum albumin are investigated by using a full-field Zernike phase contrast transmission hard X-ray microscope. From three-dimensional reconstructions and segmentations, fundamental microstructural parameters such as size, shape, distribution and volume ratio among pores and proteins inside PLGA microspheres were obtained. These parameters are useful to understand the relationship between the internal microstructure and drug encapsulation, as well as the drug release efficiency of PLGA microspheres. The presented results demonstrate the capability of hard X-ray nano-tomography to characterize porous microspheres loaded with proteins and drugs, and also open a way to analyse, optimize and design new PLGA microspheres for specific applications.
关键词hard X-ray imaging nano-tomography PLGA microspheres salt concentration drug delivery
学科领域Instruments & Instrumentation; Optics; Physics
DOI10.1107/S1600577514014611
收录类别SCI
WOS记录号WOS:000341687000035
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225171
专题多学科研究中心
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GB/T 7714
Wang, DJ,Li, N,Wang, ZL,et al. Three-dimensional study of poly(lactic co-glycolic acid) micro-porous microspheres using hard X-ray nano-tomography[J]. JOURNAL OF SYNCHROTRON RADIATION,2014,21(5):1175-1179.
APA Wang, DJ.,Li, N.,Wang, ZL.,Gao, K.,Zhang, YM.,...&Wu, ZY;吴自玉.(2014).Three-dimensional study of poly(lactic co-glycolic acid) micro-porous microspheres using hard X-ray nano-tomography.JOURNAL OF SYNCHROTRON RADIATION,21(5),1175-1179.
MLA Wang, DJ,et al."Three-dimensional study of poly(lactic co-glycolic acid) micro-porous microspheres using hard X-ray nano-tomography".JOURNAL OF SYNCHROTRON RADIATION 21.5(2014):1175-1179.
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