Three-dimensional study of poly(lactic co-glycolic acid) micro-porous microspheres using hard X-ray nano-tomography
Wang, DJ; Li, N; Wang, ZL; Gao, K; Zhang, YM; Luo, YY; Wang, SX; Bao, Y; Shao, QG; Wu, ZY;吴自玉
刊名JOURNAL OF SYNCHROTRON RADIATION
2014
卷号21期号:5页码:1175-1179
关键词hard X-ray imaging nano-tomography PLGA microspheres salt concentration drug delivery
学科分类Instruments & Instrumentation; Optics; Physics
DOI10.1107/S1600577514014611
英文摘要Poly(lactic co-glycolic acid) (PLGA) is widely used in diverse fields, especially in delivering biologically active proteins and drugs. For these applications, the knowledge of morphology and microstructure of PLGA micro-porous microspheres is of great importance since they strongly influence the drug delivering efficiency. In this study, micro-porous PLGA microspheres loaded by bovine serum albumin are investigated by using a full-field Zernike phase contrast transmission hard X-ray microscope. From three-dimensional reconstructions and segmentations, fundamental microstructural parameters such as size, shape, distribution and volume ratio among pores and proteins inside PLGA microspheres were obtained. These parameters are useful to understand the relationship between the internal microstructure and drug encapsulation, as well as the drug release efficiency of PLGA microspheres. The presented results demonstrate the capability of hard X-ray nano-tomography to characterize porous microspheres loaded with proteins and drugs, and also open a way to analyse, optimize and design new PLGA microspheres for specific applications.
收录类别SCI
WOS记录号WOS:000341687000035
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225171
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
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Wang, DJ,Li, N,Wang, ZL,et al. Three-dimensional study of poly(lactic co-glycolic acid) micro-porous microspheres using hard X-ray nano-tomography[J]. JOURNAL OF SYNCHROTRON RADIATION,2014,21(5):1175-1179.
APA Wang, DJ.,Li, N.,Wang, ZL.,Gao, K.,Zhang, YM.,...&Wu, ZY;吴自玉.(2014).Three-dimensional study of poly(lactic co-glycolic acid) micro-porous microspheres using hard X-ray nano-tomography.JOURNAL OF SYNCHROTRON RADIATION,21(5),1175-1179.
MLA Wang, DJ,et al."Three-dimensional study of poly(lactic co-glycolic acid) micro-porous microspheres using hard X-ray nano-tomography".JOURNAL OF SYNCHROTRON RADIATION 21.5(2014):1175-1179.
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